R
Raffaella Carzaniga
Researcher at Francis Crick Institute
Publications - 27
Citations - 2227
Raffaella Carzaniga is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Insulin & Homologous recombination. The author has an hindex of 18, co-authored 25 publications receiving 1945 citations. Previous affiliations of Raffaella Carzaniga include London Research Institute & Lincoln's Inn.
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Journal ArticleDOI
The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation
Suwimon Boonrungsiman,Eileen Gentleman,Raffaella Carzaniga,Nicholas D. Evans,David W. McComb,Alexandra E. Porter,Molly M. Stevens +6 more
TL;DR: A sample-preparation method that simultaneously preserved mineral, ions, and ECM with nano-analytical electron microscopy techniques to examine osteoblasts in an in vitro model of bone formation identified calcium phosphate both within osteoblast mitochondrial granules and intracellular vesicles that transported material to the ECM.
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Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants
Tamara J. Nicolson,Elisa A. Bellomo,Nadeeja Wijesekara,Merewyn K. Loder,Jocelyn M. Baldwin,Armen V. Gyulkhandanyan,Vasilij Koshkin,Andrei I. Tarasov,Raffaella Carzaniga,Katrin Kronenberger,Tarvinder K. Taneja,Gabriela da Silva Xavier,Sarah Libert,Philippe Froguel,Philippe Froguel,Raphael Scharfmann,Volodymir Stetsyuk,Philippe Ravassard,Helen E. Parker,Fiona M. Gribble,Frank Reimann,Robert Sladek,Stephen J. Hughes,Paul Johnson,Myriam Masseboeuf,Rémy Burcelin,Stephen A. Baldwin,Ming Liu,Roberto Lara-Lemus,Peter Arvan,Frans Schuit,Michael B. Wheeler,Fabrice Chimienti,Guy A. Rutter +33 more
TL;DR: ZnT8 is required for normal insulin crystallization and insulin release in vivo but not, remarkably, in vitro, and defects in the former processes in carriers of the R allele may increase type 2 diabetes risks.
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TCF7L2 regulates late events in insulin secretion from pancreatic islet β-cells.
Gabriela da Silva Xavier,Merewyn K. Loder,Angela McDonald,Andrei I. Tarasov,Raffaella Carzaniga,Katrin Kronenberger,Sebastian Barg,Guy A. Rutter +7 more
TL;DR: TCF7L2 is involved in maintaining expression of β-cell genes regulating secretory granule fusion, and defective insulin exocytosis may underlie increased diabetes incidence in carriers of the at-risk TCF 7L2 alleles.
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Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination.
Martin R.G. Taylor,Mário Špírek,Kathy R. Chaurasiya,Jordan D. Ward,Jordan D. Ward,Raffaella Carzaniga,Xiong Yu,Edward H. Egelman,Lucy M. Collinson,David Rueda,Lumir Krejci,Simon J. Boulton +11 more
TL;DR: It is proposed that Rad51 paralogs stimulate HR by remodeling the Rad51 filament, priming it for strand exchange with the template duplex, demonstrating that remodeling is essential for RFS-1/RIP-1 function.
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Trafficking of storage proteins in developing grain of wheat
TL;DR: These studies are in agreement with previous suggestions that two trafficking pathways occur in wheat, with the proteins either being transported via the Golgi apparatus into the vacuole or accumulating directly within the lumen of the ER, and suggest that the same individual protein could be trafficked by either pathway.