Eileen Gentleman

TL;DR: It is shown that ions released from strontium-substituted BG enhance metabolic activity in osteoblasts and inhibit osteoclast activity by both reducing tartrate resistant acid phosphatase activity and inhibiting resorption of calcium phosphate films in a dose-dependent manner.

TL;DR: A fundamental role for mechanosensing in mammalian development is suggested and the mechanical environment should be taken into consideration when engineering implantable scaffolds or when producing therapeutically relevant cell populations in vitro is illustrated.

TL;DR: A sample-preparation method that simultaneously preserved mineral, ions, and ECM with nano-analytical electron microscopy techniques to examine osteoblasts in an in vitro model of bone formation identified calcium phosphate both within osteoblast mitochondrial granules and intracellular vesicles that transported material to the ECM.

TL;DR: Mechanical properties of collagen as a scaffolding biomaterial for ligament replacements for tissue-engineered products must possess appropriate mechanical as well as biological/chemical properties should help enable the development of improved tissue analogues.

TL;DR: Using nano-analytical electron microscopy techniques, valves, aortae and coronary arteries from patients with and without calcific cardiovascular disease are examined and spherical calcium phosphate particles are detected, regardless of the presence of calcific lesions, suggesting mineralized spherical particles may play a fundamental role in calcific lesion formation.