E
Eileen S. Walsh
Researcher at Fox Chase Cancer Center
Publications - 5
Citations - 306
Eileen S. Walsh is an academic researcher from Fox Chase Cancer Center. The author has contributed to research in topics: Gene & Lactoylglutathione lyase. The author has an hindex of 5, co-authored 5 publications receiving 301 citations.
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Journal Article
Cloning and Characterization of Human Adenosine 5′-triphosphate-binding Cassette, Sub-family A, Transporter 2 (ABCA2)
Bojana Vulevic,Zhijian J. Chen,Jonathan T. Boyd,Warren Davis,Eileen S. Walsh,Martin G. Belinsky,Kenneth D. Tew +6 more
TL;DR: Analysis of mRNA expression levels indicated that ABCA2 is highest in human brain and has a broad expression pattern in a panel of tumor cell lines, and the presence of a lipocalin signature motif in theABCA2 sequence suggests a possible broad role for this protein in the transport of steroids, lipids, and related molecules.
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Cloning and characterization of human colon glyoxalase-I.
TL;DR: Induction of the glyoxalase-I gene expression in colon carcinomas is suggested using purified cDNA clones isolated from a human colon cDNA library using polyclonal antibodies raised against the protein purified from human colon tissue.
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Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation ☆
TL;DR: A twofold reproducible increase in reporter activity was seen with insulin and ZnCl(2) treatments, indicating a functionally operative insulin response element and metal response element (MRE).
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Glyoxalase I in detoxification: studies using a glyoxalase I transfectant cell line.
TL;DR: Transfection of a 622 bp cDNA encoding human glyoxalase I into murine NIH3T3 cells shows a consistent increase in tumour tissue when compared with pair-matched controls, suggesting increased glyoxAlase I is associated with the malignant phenotype and may also contribute to protection against the cytotoxicity of certain anti-cancer drugs.
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Promoter Analysis of a Human Dihydrodiol Dehydrogenase
TL;DR: The 5' flanking region of a human dihydrodiol dehydrogenase (DDH) gene was isolated and sequenced and contains putative binding sites for liver specific factors including NF-IL6 and HNF-5 sites and AP-1, AP-2 and NF kappa B-like sites.