E
Einat Sitbon
Researcher at Weizmann Institute of Science
Publications - 11
Citations - 1091
Einat Sitbon is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Protein structure & Conserved sequence. The author has an hindex of 9, co-authored 11 publications receiving 972 citations.
Papers
More filters
Journal ArticleDOI
Network analysis of protein structures identifies functional residues.
Gil Amitai,Arye Shemesh,Einat Sitbon,Maxim Shklar,Dvir Netanely,Ilya Venger,Shmuel Pietrokovski +6 more
TL;DR: This work transformed protein structures into residue interaction graphs (RIGs), where amino acid residues are graph nodes and their interactions with each other are the graph edges, and found that active site, ligand-binding and evolutionary conserved residues, typically have high closeness values.
Journal ArticleDOI
Chirality-induced spin polarization places symmetry constraints on biomolecular interactions.
Anup Kumar,Eyal Capua,Manoj K. Kesharwani,Jan M. L. Martin,Einat Sitbon,David H. Waldeck,Ron Naaman +6 more
TL;DR: It is shown that the charge reorganization in chiral molecules is accompanied by a polarization of the spins associated with the displaced charge, and conjecture that the spin polarization enforces symmetry constraints on the biorecognition process between two chiral molecule, and how these constraints can lead to selectivity in the interaction between enantiomers based on their handedness.
Journal ArticleDOI
hsa-miR-191 Is a Candidate Oncogene Target for Hepatocellular Carcinoma Therapy
Eran Elyakim,Einat Sitbon,Alexander Faerman,Sarit Tabak,Eve Montia,Liron Belanis,Avital Dov,Eric G. Marcusson,C. Frank Bennett,Ayelet Chajut,Dalia Cohen,Noga Yerushalmi +11 more
TL;DR: In this study, inhibition of miR-191 decreased cell proliferation and induced apoptosis in vitro and significantly reduced tumor masses in vivo in an orthotopic xenograft mouse model of HCC.
Journal ArticleDOI
Discovery of microRNAs and other small RNAs in solid tumors
Eti Meiri,Asaf Levy,Hila Benjamin,Miriam Ben-David,Lahav Cohen,Avital Dov,Nir Dromi,Eran Elyakim,Noga Yerushalmi,Orit Zion,Gila Lithwick-Yanai,Einat Sitbon +11 more
TL;DR: The sequencing of small RNAs from 23 breast, bladder, colon and lung tumor samples using high throughput sequencing is reported, and dozens of new miRNA sequence variants are identified that demonstrate the existence of miRNA-related SNP or post-transcriptional modifications.
Journal ArticleDOI
Occurrence of protein structure elements in conserved sequence regions
Einat Sitbon,Shmuel Pietrokovski +1 more
TL;DR: The detailed statistical analysis of diverse proteins links protein evolution to the biophysics of protein thermodynamic stability and folding and the basic structural features of conserved sequence regions are identified.