E
Elda Del Giudice
Researcher at University of Camerino
Publications - 23
Citations - 969
Elda Del Giudice is an academic researcher from University of Camerino. The author has contributed to research in topics: Receptor & Medicine. The author has an hindex of 13, co-authored 20 publications receiving 904 citations. Previous affiliations of Elda Del Giudice include Chiesi Farmaceutici S.p.A..
Papers
More filters
Journal ArticleDOI
Cannabinoids ablate release of TNFalpha in rat microglial cells stimulated with lypopolysaccharide.
TL;DR: The data indicate that both synthetic and endogenous cannabinoids inhibit LPS‐induced release of TNFα from microglial cells, providing evidence suggestive of the existence of yet unidentified cannabinoid receptor(s) in brain microglia.
Journal ArticleDOI
Synthesis and Biological Activity of Flurbiprofen Analogues as Selective Inhibitors of β-Amyloid1-42 Secretion
Ilaria Peretto,Stefano Radaelli,Carlo Parini,Michele Zandi,Luca F. Raveglia,Giulio Dondio,Laura Fontanella,Paola Misiano,Chiara Bigogno,Andrea Rizzi,Benedetta Riccardi,Marcello Biscaioli,Silvia Marchetti,Paola Puccini,Silvia Catinella,Ivano Rondelli,Valentina Cenacchi,Pier Tonino Bolzoni,Paola Caruso,Gino Villetti,Fabrizio Facchinetti,Elda Del Giudice,Nadia Moretto,Bruno P. Imbimbo +23 more
TL;DR: New flurbiprofen analogues were synthesized, with the aim of increasing Aβ42 inhibitory potency while removing anti-COX activity, and some of the compounds appeared to be well absorbed after oral administration and to penetrate into the central nervous system in rats.
Journal ArticleDOI
In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand.
Cristina Marzano,Valentina Gandin,Maura Pellei,Davide Colavito,Grazia Papini,Giancarlo Gioia Lobbia,Elda Del Giudice,Marina Porchia,Francesco Tisato,Carlo Santini +9 more
TL;DR: Cytological stains and flow cytometric analyses indicated that the phosphine copper(I) complex is able to inhibit the growth of tumor cells via G2/M cell cycle arrest and paraptosis accompanied with the loss of mitochondrial transmembrane potential.
Journal ArticleDOI
1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
Bruno P. Imbimbo,Elda Del Giudice,Davide Colavito,Antonello D'Arrigo,Maurizio Dalle Carbonare,Gino Villetti,Fabrizio Facchinetti,Roberta Volta,Vladimiro Pietrini,Maria Francesca Baroc,Lutgarde Serneels,Bart De Strooper,Alberta Leon +12 more
TL;DR: 1-(3′,4′-Dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074) is a new γ-secretase modulator, devoid of anticyclooxygenase (COX) and Notch-interfering activities in vitro, and is therefore a promising therapeutic agent for Alzheimer's disease.
Journal ArticleDOI
CHF5074, a Novel γ-Secretase Modulator, Restores Hippocampal Neurogenesis Potential and Reverses Contextual Memory Deficit in a Transgenic Mouse Model of Alzheimer's Disease
Bruno P. Imbimbo,Luciana Giardino,Sandra Sivilia,Alessandro Giuliani,Marco Gusciglio,Vladimiro Pietrini,Elda Del Giudice,Antonello D'Arrigo,Alberta Leon,G Villetti,Laura Calzà +10 more
TL;DR: The effects of long-term treatment with CHF5074, a new gamma-secretase modulator, on hippocampal neurogenesis, cortical synaptophysin levels, and contextual memory in transgenic mice carrying the double Swedish mutation of AbetaPP are evaluated.