L
Lutgarde Serneels
Researcher at Katholieke Universiteit Leuven
Publications - 68
Citations - 7684
Lutgarde Serneels is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Presenilin & Amyloid precursor protein. The author has an hindex of 36, co-authored 63 publications receiving 7057 citations. Previous affiliations of Lutgarde Serneels include Universitaire Ziekenhuizen Leuven & Allen Institute for Brain Science.
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Journal ArticleDOI
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Dieter Hartmann,Bart De Strooper,Lutgarde Serneels,Kathleen Craessaerts,An Herreman,Wim Annaert,Lieve Umans,Torben Lübke,Anna Lena Illert,Kurt von Figura,Paul Saftig +10 more
TL;DR: Results indicate that either a regulation between ADAMs on the post-translational level or that other, not yet known, proteases are able to compensate for ADAM 10 deficiency, and points to the existence of tissue-specific 'teams' of different proteases exerting alpha-secretase activity.
Journal ArticleDOI
Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling
Sara Cipolat,Tomasz Rudka,Dieter Hartmann,Veronica Costa,Lutgarde Serneels,Katleen Craessaerts,Kristine Metzger,Christian Frezza,Wim Annaert,Luciano D'Adamio,Carmen Derks,Tim Dejaegere,Luca Pellegrini,Rudi D'Hooge,Luca Scorrano,Bart De Strooper +15 more
TL;DR: Findings implicate regulated intramembrane proteolysis in controlling apoptosis in Parl-/- mice, substantiating the importance of PARL in OPA1 processing.
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Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.
Huiping Tu,Omar L. Nelson,Arseny Bezprozvanny,Zhengnan Wang,Sheu Fen Lee,Yi Heng Hao,Lutgarde Serneels,Bart De Strooper,Gang Yu,Ilya Bezprozvanny +9 more
TL;DR: It is demonstrated that wild-type presenilins, but not PS1-M146V and PS2-N141I FAD mutants, can form low-conductance divalent-cation-permeable ion channels in planar lipid bilayers.
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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
An Herreman,Dieter H. Hartmann,Wim Annaert,Paul Saftig,Katleen Craessaerts,Lutgarde Serneels,Lieve Umans,Vincent Schrijvers,Frédéric Checler,Hugo Vanderstichele,Veerle Baekelandt,Ralf Dressel,Philippe Cupers,Danny Huylebroeck,An Zwijsen,Fred Van Leuven,Bart De Strooper +16 more
TL;DR: It is demonstrated in vivo that PS1 and PS2 have partially overlapping functions and thatPS1 is essential andPS2 is redundant for normal Notch signaling during mammalian embryological development.
Journal ArticleDOI
Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.
TL;DR: The question of how proteins such as the β-amyloid precursor protein (β-APP), Notch-1 and others can be cleaved in the plane of the membrane has challenged cell biologists and researchers into Alzheimer’s disease for some time and γ-secretase activity is considered an important therapeutic target.