Laura Calzà

TL;DR: EDCs, from varied sources, may have organisational effects during development and/or activational effects in adulthood that influence sexually‐dimorphic, reproductively‐relevant processes or other functions, by mimicking, antagonising or altering steroidal actions.

TL;DR: The effect of GM1 ganglioside on the recovery of nigro-strital dopaminergic neurons was studied in rats after unilateral hemitransection and it is found that repeated administration ofGM1 significantly increased the HVA content, the tyrosine hydroxylase activity and the tyosine hydoxylase-related immunofluorescence in the striatum ipsilateral to the lesion.

TL;DR: It is introduced that following ganglioside treatment some lesioned DA nerve cells do not degenerate, but elongate their dendrites to give increased trophic support to DA cell bodies with intact DA axons, and may possibly represent a new type of drug in the treatment of Parkinson's disease and aging processes in DA systems.

TL;DR: The present investigation suggests that the increase of scg size induced by NGF and 6-OHDA + NGF is associated with neoangiogenesis, and that the induction of vasoactive and angiogenic factors in neurons represents a further and previously undisclosed effect of NGF.

TL;DR: Results show that early pharmacotherapy with a drug usable by humans can correct neurogenesis and behavioral impairment in a model for DS, and that proliferation was completely rescued by fluoxetine.