Elena Burova

TL;DR: This work has engineer a very potent high-affinity VEGF blocker that has markedly enhanced pharmacokinetic properties and effectively suppresses tumor growth and vascularization in vivo, resulting in stunted and almost completely avascular tumors.

TL;DR: The mechanism by which MYH is depleted under atrophy conditions is identified and it is demonstrated that inhibition of a single E3 ligase, MuRF1, is sufficient to maintain this important sarcomeric protein.

TL;DR: The data suggest a novel, tissue-specific role for the Akt/FKHR pathway in the vasculature and suggest a mechanistic basis for the previously described actions of Ang-1 as a regulator of endothelial cell survival and blood vessel stability.

TL;DR: In this article, the authors proposed a method of using antibodies that bind to the T-cell co-inhibitor programmed death-1 (PD-1 ) protein and methods of use.

TL;DR: It is demonstrated that Ang-2 expression is rapidly induced in endothelial cells by the transcription factor FOXO1 after inhibition of the phosphatidylinositol 3-kinase/Akt pathway, which suggests a model in which Ang-1 acts as an autocrine Tie2 agonist and protective factor.