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Eleni T. Tzavara
Researcher at University of Paris
Publications - 76
Citations - 6358
Eleni T. Tzavara is an academic researcher from University of Paris. The author has contributed to research in topics: Cannabinoid & Dopamine. The author has an hindex of 36, co-authored 72 publications receiving 5966 citations. Previous affiliations of Eleni T. Tzavara include Pierre-and-Marie-Curie University & Paris Descartes University.
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Journal ArticleDOI
Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene.
Hans W. D. Matthes,Rafael Maldonado,Frédéric Simonin,Olga Valverde,Susan Slowe,Ian Kitchen,Katia Befort,Andrée Dierich,Marianne Le Meur,Pascal Dollé,Eleni T. Tzavara,Jacques Hanoune,Bernard P. Roques,Brigitte L. Kieffer +13 more
TL;DR: Investigation of the behavioural effects of morphine reveals that a lack of μ receptors abolishes the analgesic effect of morphine, as well as place-preference activity and physical dependence, and concludes that the µ-opioid-receptor gene product is a mandatory component of the opioid system for morphine action.
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Diverse psychotomimetics act through a common signaling pathway.
Per Svenningsson,Eleni T. Tzavara,Robert Carruthers,Ilan Rachleff,Sigrid Wattler,Michael Nehls,David L. McKinzie,Allen A. Fienberg,George G. Nomikos,Paul Greengard +9 more
TL;DR: In mice with a genetic deletion of DAR PP-32 or with point mutations in phosphorylation sites of DARPP-32, the effects of D-amphetamine, LSD, and PCP on two behavioral parameters—sensorimotor gating and repetitive movements—were strongly attenuated.
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Reduction of Morphine Abstinence in Mice with a Mutation in the Gene Encoding CREB
Rafael Maldonado,Julie A. Blendy,Eleni T. Tzavara,Peter Gass,Bernard P. Roques,Jacques Hanoune,Günther Schütz +6 more
TL;DR: CREB-dependent gene transcription is a factor in the onset of behavioral manifestations of opiate dependence and the main symptoms of morphine withdrawal were strongly attenuated.
Journal ArticleDOI
The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions
Eleni T. Tzavara,Richard J. Davis,Kenneth W. Perry,Xia Li,Craig R. Salhoff,Frank P. Bymaster,Jeffrey M. Witkin,George G. Nomikos +7 more
TL;DR: The results suggest that the cortical selectivity in the release of catecholamines, dopamine in particular, induced by the cannabinoid antagonist SR141716A, its procholinergic properties, together with its mild stimulatory effects on serotonin and norepinephrine efflux make similar compounds unique candidates for the treatment of psychosis, affective and cognitive disorders.
Journal ArticleDOI
Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac).
Per Svenningsson,Eleni T. Tzavara,Jeffrey M. Witkin,Allen A. Fienberg,George G. Nomikos,Paul Greengard +5 more
TL;DR: It is shown that, in vivo, fluoxetine, given either acutely or chronically, regulates the phosphorylation state of dopamine- and cAMP-regulated phosphoprotein of Mr 32,000 (DARPP-32) at multiple sites in prefrontal cortex, hippocampus, and striatum.