Sigrid Wattler

TL;DR: It is shown that missense point mutations in the cytoplasmic dynein heavy chain result in progressive motor neuron degeneration in heterozygous mice, and in homozygotes this is accompanied by the formation of Lewy-like inclusion bodies, thus resembling key features of human pathology.

TL;DR: The results indicate that Eomesodermin defines a conserved molecular pathway controlling the morphogenetic movements of germ layer formation and has acquired a new function in mammals in the differentiation of trophoblast.

TL;DR: In mice with a genetic deletion of DAR PP-32 or with point mutations in phosphorylation sites of DARPP-32, the effects of D-amphetamine, LSD, and PCP on two behavioral parameters—sensorimotor gating and repetitive movements—were strongly attenuated.

TL;DR: A role for PARG in embryonic development and a protective role in the response to genotoxic stress are defined, providing compelling evidence that the failure to degrade PAR has deleterious consequences.

TL;DR: It is demonstrated that a murine homologue of human β-defensin 2 is present in the respiratory system and other mucosal surfaces and further impetus to evaluate the mouse as a model for studying the human innate host defense system.