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Eleonora Melzi
Researcher at Massachusetts Institute of Technology
Publications - 12
Citations - 422
Eleonora Melzi is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Antibody & Immune system. The author has an hindex of 8, co-authored 11 publications receiving 285 citations. Previous affiliations of Eleonora Melzi include Ragon Institute of MGH, MIT and Harvard & University of Glasgow.
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Journal ArticleDOI
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses
Jon M. Steichen,Ying-Cing Lin,Colin Havenar-Daughton,Colin Havenar-Daughton,Simone Pecetta,Gabriel Ozorowski,Jordan R. Willis,Laura Toy,Laura Toy,Devin Sok,Alessia Liguori,Sven Kratochvil,Jonathan L. Torres,Oleksandr Kalyuzhniy,Eleonora Melzi,Daniel W. Kulp,Sebastian Raemisch,Xiaozhen Hu,Steffen M. Bernard,Erik Georgeson,Nicole Phelps,Yumiko Adachi,Michael Kubitz,Elise Landais,Jeffrey C. Umotoy,Amanda M Robinson,Bryan Briney,Ian A. Wilson,Dennis R. Burton,Andrew B. Ward,Shane Crotty,Shane Crotty,Shane Crotty,Facundo D. Batista,Facundo D. Batista,William R. Schief +35 more
TL;DR: Among several new vaccine strategies, germline-targeting vaccine design aims to induce bnAbs by first stimulating bnAb-precursor B cells and then shepherding B cell affinity maturation with a series of rationally designed boosting immunogens.
Journal ArticleDOI
Characterization of a second open reading frame in genome segment 10 of bluetongue virus.
Meredith Stewart,Alexandra Hardy,Gerald Barry,Rute Maria Pinto,Marco Caporale,Eleonora Melzi,Joseph Hughes,Aislynn Taggart,Aislynn Janowicz,M. Varela,Maxime Ratinier,Massimo Palmarini +11 more
TL;DR: The data presented provide an initial characterization of this ORF and in both mammalian and insect cells, BTV S10-ORF2 deletion mutants (BTV8ΔS10- ORF2) displayed similar replication kinetics to wt virus.
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Follicular dendritic cell disruption as a novel mechanism of virus-induced immunosuppression.
Eleonora Melzi,Marco Caporale,Mara Rocchi,Verónica Martín,Virginia Gamino,Andrea Di Provvido,Giuseppe Marruchella,Gary Entrican,Noemí Sevilla,Massimo Palmarini +9 more
TL;DR: It is discovered that BTV modulates the humoral immune response by rapidly infecting and destroying follicular dendritic cells (FDCs) in the host LNs, which results in a delayed production of high affinity and virus neutralizing antibodies.
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One-step CRISPR/Cas9 method for the rapid generation of human antibody heavy chain knock-in mice.
Ying-Cing Lin,Simone Pecetta,Jon M. Steichen,Sven Kratochvil,Eleonora Melzi,Johan Arnold,Stephanie K. Dougan,Lin Wu,Kathrin H Kirsch,Usha Nair,William R. Schief,William R. Schief,Facundo D. Batista +12 more
TL;DR: A one‐step, in vivo CRISPR/Cas9 nuclease‐mediated strategy to generate knock‐in mice that will provide much needed vaccination models to evaluate immunoresponses against immunogens specific for various infectious diseases is described.
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Peripheral blood abnormalities and bone marrow infiltration in canine large B-cell lymphoma: is there a link?
TL;DR: It is suggested that blood abnormalities are not always predictive of marrow involvement, even if thrombocytopenia, leucocytosis or lymphocytotic could suggest a higher infiltration, and BM evaluation should be included in routine staging in order not to miss infiltrated samples and to improve classification.