Alexandra Hardy

TL;DR: The data presented provide an initial characterization of this ORF and in both mammalian and insect cells, BTV S10-ORF2 deletion mutants (BTV8ΔS10- ORF2) displayed similar replication kinetics to wt virus.

TL;DR: In this article , a functional CRISPR/Cas9 screen aiming at identifying SARS-CoV-2 restriction factors was described, and DAXX, a scaffold protein residing in PML nuclear bodies known to limit the replication of DNA viruses and retroviruses, was identified as a potent inhibitor of SARS CoV2 and SARSCoV replication in human cells.

TL;DR: Results indicate that adaptation at the T179 residue in MAYV E2 may result in increased vector competence – but coming at the cost of optimal replication in humans – and may represent a first step towards a future emergence event.

TL;DR: It is determined that BTV reaches higher titres in ovine cells, compared to bovine cells although it induces comparable levels of antiviral cytokines in both cell types, and pre-treatment with interferon severely hampers BTV replication in bovines, but not in Ovine, primary cells.

TL;DR: It is demonstrated that BTV induces a faster host cell protein synthesis shutoff in primary sheep cells, compared to cattle cells, which results in an earlier downregulation of antiviral proteins, which provides a new perspective on how the type-I IFN response in reservoir species can have overall positive effects on both virus and host evolution.