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Andrew B. Ward
Researcher at Scripps Research Institute
Publications - 433
Citations - 39187
Andrew B. Ward is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Epitope & Antibody. The author has an hindex of 91, co-authored 368 publications receiving 30332 citations. Previous affiliations of Andrew B. Ward include International AIDS Vaccine Initiative & Scripps Health.
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Journal ArticleDOI
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Stephen G. Aller,Jodie Yu,Andrew B. Ward,Yue Weng,Srinivas Chittaboina,Rupeng Zhuo,Patina M. Harrell,Yenphuong T. Trinh,Qinghai Zhang,Ina L. Urbatsch,Geoffrey Chang +10 more
TL;DR: P-glycoprotein detoxifies cells by exporting hundreds of chemically unrelated toxins but has been implicated in multidrug resistance (MDR) in the treatment of cancers and a structural description of poly-specific drug-binding is important for the rational design of anticancer drugs and MDR inhibitors.
Journal ArticleDOI
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability.
Philip J. M. Brouwer,Tom G. Caniels,Karlijn van der Straten,Jonne L. Snitselaar,Yoann Aldon,Sandhya Bangaru,Jonathan L. Torres,Nisreen M.A. Okba,Mathieu Claireaux,Gius Kerster,Arthur E. H. Bentlage,Marlies M. van Haaren,Denise Guerra,Judith A. Burger,Edith E. Schermer,Kirsten D. Verheul,Niels van der Velde,Alex van der Kooi,Jelle van Schooten,Mariëlle J. van Breemen,Tom P. L. Bijl,Kwinten Sliepen,Aafke Aartse,Aafke Aartse,Ronald Derking,Ilja Bontjer,Neeltje A. Kootstra,W. Joost Wiersinga,Gestur Vidarsson,Bart L. Haagmans,Andrew B. Ward,Godelieve J. de Bree,Rogier W. Sanders,Rogier W. Sanders,Marit J. van Gils +34 more
TL;DR: It is shown that the patients had strong immune responses against the viral spike protein, a complex that binds to receptors on the host cell, and monoclonal antibodies isolated here are promising candidates for COVID-19 treatment and prevention.
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Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
Jesper Pallesen,Nianshuang Wang,Kizzmekia S. Corbett,Daniel Wrapp,Robert N. Kirchdoerfer,Hannah L. Turner,Christopher A. Cottrell,Michelle M. Becker,Lingshu Wang,Wei Shi,Wing-Pui Kong,Erica L. Andres,Arminja N. Kettenbach,Mark R. Denison,Mark R. Denison,James D. Chappell,Barney S. Graham,Andrew B. Ward,Jason S. McLellan +18 more
TL;DR: An engineering strategy for stabilization of soluble S proteins in the prefusion conformation is described, which results in greatly increased expression, conformational homogeneity, and elicitation of potent antibody responses, and an engineered immunogen is able to elicit high neutralizing antibody titers against MERS-CoV.
Journal ArticleDOI
A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies
Rogier W. Sanders,Rogier W. Sanders,Ronald Derking,Albert Cupo,Jean-Philippe Julien,Anila Yasmeen,Natalia de Val,Helen J. Kim,Claudia Blattner,Alba Torrents de la Peña,Jacob Korzun,Michael Golabek,Kevin de los Reyes,Thomas J. Ketas,Marit J. van Gils,C. Richter King,Ian A. Wilson,Andrew B. Ward,Per Johan Klasse,John P. Moore +19 more
TL;DR: The design and properties of soluble, cleaved SOSIP trimers based on the subtype A transmitted/founder strain, BG505, are described, which are highly stable and homogenous and closely resemble native virus spikes when visualized by negative stain electron microscopy (EM).
Journal ArticleDOI
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
Jason S. McLellan,Marie Pancera,Chris Carrico,Jason Gorman,Jean-Philippe Julien,Reza Khayat,Robert K. Louder,Robert Pejchal,Mallika Sastry,Kaifan Dai,Sijy O'Dell,Nikita Patel,Syed Shahzad-ul-Hussan,Yongping Yang,Baoshan Zhang,Tongqing Zhou,Jiang Zhu,Jeffrey C. Boyington,Gwo-Yu Chuang,Devan Diwanji,Ivelin S. Georgiev,Young Do Kwon,Doyung Lee,Mark K. Louder,Stephanie Moquin,Stephen D. Schmidt,Zhi Yong Yang,Mattia Bonsignori,John A. Crump,John A. Crump,Saidi Kapiga,Noel E. Sam,Barton F. Haynes,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,Laura M. Walker,Sanjay Phogat,Richard T. Wyatt,Jared Orwenyo,Lai-Xi Wang,James Arthos,Carole A. Bewley,John R. Mascola,Gary J. Nabel,William R. Schief,William R. Schief,Andrew B. Ward,Ian A. Wilson,Peter D. Kwong +49 more
TL;DR: The structure of V1/V2 in complex with PG9 is reported, identifying a paradigm of antibody recognition for highly glycosylated antigens, which—with PG9—involves a site of vulnerability comprising just two glycans and a strand.