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Eline Bartolami
Researcher at University of Geneva
Publications - 19
Citations - 655
Eline Bartolami is an academic researcher from University of Geneva. The author has contributed to research in topics: Dynamic covalent chemistry & Ion homeostasis. The author has an hindex of 12, co-authored 19 publications receiving 515 citations. Previous affiliations of Eline Bartolami include École nationale supérieure de chimie de Montpellier & Centre national de la recherche scientifique.
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Journal ArticleDOI
Efficient Delivery of Quantum Dots into the Cytosol of Cells Using Cell-Penetrating Poly(disulfide)s
TL;DR: This work introduces a technology based on cell-penetrating poly(disulfide)s that delivers about 70 QDs per cell, and 90% appear to freely diffuse in the cytosol, paving the way toward single molecule imaging in cells and living animals.
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Strained Cyclic Disulfides Enable Cellular Uptake by Reacting with the Transferrin Receptor.
Daniel Abegg,Giulio Gasparini,Dominic Gregor Hoch,Anton Shuster,Eline Bartolami,Stefan Matile,Alexander Adibekian +6 more
TL;DR: This study demonstrates that appendage of a single asparagusic acid residue (AspA tag) is sufficient to ensure efficient cellular uptake and intracellular distribution of fully unprotected peptides and applies this new delivery method to induce apoptotic response in cancer cells using long (up to 20mer) BH3 domain peptides.
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A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell.
Yasunori Okamoto,Ryosuke Kojima,Ryosuke Kojima,Fabian Schwizer,Eline Bartolami,Tillmann Heinisch,Stefan Matile,Martin Fussenegger,Thomas R. Ward +8 more
TL;DR: It is shown that such hybrid catalysts consisting of a metal cofactor, a cell-penetrating module, and a protein scaffold are taken up into HEK-293T cells where they catalyze the uncaging of a hormone.
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Emerging trends in enzyme inhibition by multivalent nanoconstructs
Nasreddine Kanfar,Eline Bartolami,Renaud Zelli,Alberto Marra,Jean-Yves Winum,Sébastien Ulrich,Pascal Dumy +6 more
TL;DR: The recent results highlighting the potential of multivalent nanoconstructs for the inhibition of different enzymes, and the emerging trends in the generation and identification ofMultivalent clusters as enzyme inhibitors are reviewed.
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Epidithiodiketopiperazines: Strain-Promoted Thiol-Mediated Cellular Uptake at the Highest Tension.
TL;DR: The results suggest that ETP-mediated uptake not only maximizes delivery to the cytosol and nucleus but also opens the door to a new multitarget hopping mode of action.