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Elisabeth Tournier-Lasserve
Researcher at University of Paris
Publications - 194
Citations - 14570
Elisabeth Tournier-Lasserve is an academic researcher from University of Paris. The author has contributed to research in topics: CADASIL & Leukoencephalopathy. The author has an hindex of 56, co-authored 173 publications receiving 13001 citations. Previous affiliations of Elisabeth Tournier-Lasserve include Boston Children's Hospital & University of Tübingen.
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Journal ArticleDOI
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
Anne Joutel,Christophe Corpechot,Anne Ducros,Katayoun Vahedi,Hugues Chabriat,Philippe Mouton,Sonia Alamowitch,Valérie Domenga,Michaelle Cécillion,Emmanuelle Maréchal,Jacqueline Maciazek,Céline Vayssière,Corinne Cruaud,E. A. Cabanis,Marie Madeleine Ruchoux,Jean Weissenbach,Jean Francois Bach,Marie-Germaine Bousser,Elisabeth Tournier-Lasserve +18 more
TL;DR: The characterization of the human Notch3 gene, which was previously mapped to the CADASIL critical region, is reported, indicating that Notch 3 could be the defective protein in CADASil patients.
Journal ArticleDOI
The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications
Elisabetta Dejana,Elisabeth Tournier-Lasserve,Elisabeth Tournier-Lasserve,Brant M. Weinstein +3 more
TL;DR: This review discusses recent findings derived from basic cell biology, clinical studies, and studies in animal models such as mice and zebrafish and their possible integration in a common picture of human pathologies.
Journal ArticleDOI
Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients
Anne Joutel,Katayoun Vahedi,Christophe Corpechot,Alain Troesch,Hugues Chabriat,Céline Vayssière,Corinne Cruaud,Jacqueline Maciazek,Jean Weissenbach,Marie-Germaine Bousser,Jean-François Bach,Elisabeth Tournier-Lasserve +11 more
TL;DR: The findings suggest that aberrant dimerisation of Notch3, due to abnormal disulphide bridging with another NotCh3 molecule or with another protein, may be involved in the pathogenesis of this disorder.
Journal ArticleDOI
The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients
Anne Joutel,F. Andreux,Swann Gaulis,Valérie Domenga,Michaelle Cecillon,Nicole Battail,Nadia Piga,Françoise Chapon,Catherine Godfrain,Elisabeth Tournier-Lasserve +9 more
TL;DR: Results strongly suggest that CADASIL mutations specifically impair the clearance of the Notch3 ectodomain, but not the cytosolic domain, from the cell surface.
Journal ArticleDOI
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
Valérie Domenga,Peggy Fardoux,Pierre Lacombe,Marie Monet,Jacqueline Maciazek,Luke T. Krebs,Bernard Klonjkowski,Eliane Berrou,Matthias Mericskay,Zhen Li,Elisabeth Tournier-Lasserve,Thomas Gridley,Anne Joutel +12 more
TL;DR: Notch3 is revealed to be the first cell-autonomous regulator of arterial differentiation and maturation of vascular smooth muscle cells (vSMC) and required for arterial specification of vSMC but not of endothelial cells.