E
Elise Thomas
Researcher at Massachusetts Institute of Technology
Publications - 4
Citations - 1794
Elise Thomas is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene & Immunoglobulin heavy chain. The author has an hindex of 4, co-authored 4 publications receiving 1776 citations. Previous affiliations of Elise Thomas include Tufts University.
Papers
More filters
Journal ArticleDOI
Ordered rearrangement of immunoglobulin heavy chain variable region segments.
Frederick W. Alt,George D. Yancopoulos,T K Blackwell,Charles E. Wood,Elise Thomas,Michael Alan Boss,Robert L. Coffman,Naomi Rosenberg,Susumu Tonegawa,David Baltimore +9 more
TL;DR: Results support an ordered mechanism of variable gene assembly during B‐cell differentiation in which D‐to‐JH rearrangements generally occur first and on both chromosomes followed by VH‐to-DJH rearranged, with both types of joining processes occurring by intrachromosomal deletion.
Journal ArticleDOI
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells
Stephen V. Desiderio,George D. Yancopoulos,Michael Paskind,Elise Thomas,Elise Thomas,Michael Alan Boss,Nathaniel R. Landau,Frederick W. Alt,David Baltimore +8 more
TL;DR: This work isolated and sequenced molecular clones representing intermediates (DJH fusions) and final products ( VH-to-DJH joins) of heavy-chain gene rearrangement in two cell lines that represent analogues of cells at early stages of B-lymphocyte differentiation.
Journal ArticleDOI
Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes
TL;DR: The structure of immunoglobulin-related gene was analyzed in individual Abelson murine leukemia virus (A-MuLV)-transformed lymphoid cell lines and appears to precede that of light chain gene rearrangement and is still continuing in certain cultured A- MuLV transformants.
Journal ArticleDOI
Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line
Frederick W. Alt,Frederick W. Alt,Naomi Rosenberg,Rose J. Casanova,Elise Thomas,David Baltimore +5 more
TL;DR: A cell line that switches from μ to γ2b synthesis during growth in culture uses the same VH region for both heavy chains but retains two copies of the Cμ gene, suggesting that the μ toγ2b class switch can occur, at least in part, by an RNA processing mechanism.