E
Elizabeth Baronas
Researcher at Millennium Pharmaceuticals
Publications - 5
Citations - 4284
Elizabeth Baronas is an academic researcher from Millennium Pharmaceuticals. The author has contributed to research in topics: Carboxypeptidase & Angiotensin-converting enzyme. The author has an hindex of 5, co-authored 5 publications receiving 3760 citations.
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Journal ArticleDOI
A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9
Mary Donoghue,Frank Y. Hsieh,Elizabeth Baronas,Kevin Godbout,Michael Gosselin,Nancy E. Stagliano,Michael J. Donovan,Betty Woolf,Keith E. Robison,Raju Jeyaseelan,Roger E. Breitbart,Susan L. Acton +11 more
TL;DR: The organ- and cell-specific expression of ACE2 and its unique cleavage of key vasoactive peptides suggest an essential role for ACE2 in the local renin-angiotensin system of the heart and kidney.
Journal ArticleDOI
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.
Chad S Vickers,Paul Hales,Virendar K. Kaushik,Larry Dick,James M. Gavin,Jin Tang,Kevin Godbout,Thomas F. Parsons,Elizabeth Baronas,Frank Y. Hsieh,Susan L. Acton,Michael A. Patane,Andrew J. Nichols,Peter J. Tummino +13 more
TL;DR: The physiological role of ACE2 is elucidated, and its catalytic activity was characterized, and a consensus sequence of: Pro-X (1–3 residues)-Pro-Hydrophobic, where hydrolysis occurs between proline and the hydrophobic amino acid is revealed.
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Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites.
Teresa M. Pekol,J. Scott Daniels,Jason Labutti,Ian Parsons,Darrell Nix,Elizabeth Baronas,Frank Y. Hsieh,Liang-Shang Gan,Gerald T. Miwa +8 more
TL;DR: The development of bortezomib has provided an opportunity to describe the metabolism of a novel boronic acid pharmacophore, as the principal circulating metabolites were observed in vitro.
Journal ArticleDOI
Biomarkers to monitor drug-induced phospholipidosis.
TL;DR: Urinary levels of di-docosahexaenoyl (C22:6)-bis(monoacylglycerol) phosphate (BMP) correlated with induction of phospholipidosis for amiodarone, gentamicin and azithromycin.
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A novel nanospray capillary zone electrophoresis/mass spectrometry interface.
TL;DR: The results showed mixtures of peptides were highly resolved within a few minutes and the novel CZE/ESI-TOFMS interface may simultaneously provide sensitivity, data acquisition speed, mass range, and mass resolution while maintaining resolution of the CZE separation.