Elizabeth Di Lullo

TL;DR: The results support a mixed model of topographical, typological, and temporal hierarchies governing cell-type diversity in the developing human telencephalon, including distinct excitatory lineages emerging in rostral and caudal cerebral cortex.

TL;DR: Recent advances in stem cell technologies that enable the generation of human brain organoids from pluripotent stem cells (PSCs) promise to profoundly change understanding of the development of the human brain and enable a detailed study of the pathogenesis of inherited and acquired brain diseases.

TL;DR: Examining the expression of receptors implicated in cell entry of several enveloped viruses including ZIKV across diverse cell types in the developing brain found that the candidate viral entry receptor AXL is highly expressed by human radial glial cells, astrocytes, endothelial cells, and microglia in developing human cortex and by progenitor cells in developing retina.

TL;DR: It is concluded that blood-derived TAMs significantly infiltrate pre-treatment gliomas, to a degree that varies by glioma subtype and tumor compartment, and a novel signature that distinguishes TAMs by ontogeny in humangliomas is presented.

TL;DR: Cerebral organoids derived from control and MDS-induced pluripotent stem cells (iPSCs) are analyzed and a mitotic defect in outer radial glia is identified, a progenitor subtype that is largely absent from lissencephalic rodents but critical for human neocortical expansion.