Anne A. Leyrat

TL;DR: This paper identifies diverse cell types, including multiple progenitor and neuronal subtypes, and identifies EGR1 and FOS as previously unreported candidate targets of Notch signaling in human but not mouse radial glia by microfluidic single-cell capture and low-coverage sequencing of many cells.

TL;DR: The results support a mixed model of topographical, typological, and temporal hierarchies governing cell-type diversity in the developing human telencephalon, including distinct excitatory lineages emerging in rostral and caudal cerebral cortex.

TL;DR: It is suggested that outer radial glia directly support the subventricular niche through local production of growth factors, potentiation of growth factor signals by extracellular matrix proteins, and activation of self-renewal pathways, thereby enabling the developmental and evolutionary expansion of the human neocortex.

TL;DR: This work leveraged recent innovations that permit generating pluripotent stem cell-derived cerebral organoids from chimpanzee to identify human-specific features of cortical development and identifies 261 differentially expressed genes in human compared to both chimpanzee organoids and macaque cortex.

TL;DR: It is shown that miRNA-mRNA interactions operate as functional modules that often correspond to cell-type identities and undergo dynamic transitions during brain development, which are highly dynamic during development and over the course of evolution.