Elizabeth F. Brigham

TL;DR: It is demonstrated unequivocally that elderly human microglia provide a brain endogenous source for a wide range of inflammatory mediators.

TL;DR: The overall gene expression pattern during this “physiologically inappropriate” apoptotic stimulus is markedly similar to the pattern the authors previously identified after a “ Physiologically appropriate” stimulus, Hence, the parallels identified here further the understanding of the genetic alterations that may lead neurons to apoptosis in response to markedly different insults.

TL;DR: Evidence is submitted that polo-like kinase 2 (PLK2), also known as serum-inducible kinase or SNK, is a principle contributor to α-synuclein phosphorylation at Ser-129 in neurons in neurons.

TL;DR: Findings indicate that OSM or IL-6·sIL-6 complexes may regulate ACT expression in human astrocytes and thus directly or indirectly contribute to the pathogenesis of Alzheimer’s disease.

TL;DR: The phenotype of the L RRK2 null rat is suggestive of a complex biology influencing metabolism, immune function and kidney homeostasis, and Ontological pathway analysis of LRRK2 across metabolic and kidney processes and pathological categories suggested that the thioredoxin network may play a role in perturbing these organ systems.