E
Elizabeth Galbreath
Researcher at Eli Lilly and Company
Publications - 20
Citations - 2822
Elizabeth Galbreath is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: T cell & Sepsis. The author has an hindex of 11, co-authored 18 publications receiving 2578 citations.
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Journal ArticleDOI
FGF-21 as a novel metabolic regulator
Alexei Kharitonenkov,Tatiyana L. Shiyanova,Anja Koester,Amy M. Ford,Radmila Micanovic,Elizabeth Galbreath,George E. Sandusky,Lisa Janine Hammond,Julie S. Moyers,Owens Rebecca Anne,Jesper Gromada,Joseph T. Brozinick,Eric D. Hawkins,Victor J. Wroblewski,De Shan Li,Farrokh Mehrbod,S. Richard Jaskunas,Armen B. Shanafelt +17 more
TL;DR: It is concluded that FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
Journal ArticleDOI
Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor.
George H. Searfoss,William H. Jordan,David O. Calligaro,Elizabeth Galbreath,Linda M. Schirtzinger,Brian R. Berridge,Hong Gao,Marnie A. Higgins,Patrick C. May,Timothy P. Ryan +9 more
TL;DR: It is proposed that adipsin is a Hes-1-regulated gene that is de-repressed during FGSI-mediated disruption of Notch/Hes-1 signaling, and its presence in feces may serve as a noninvasive biomarker of gastrointestinal toxicity associated with perturbed Notch signaling.
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LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice
Kristan A. Keyes,Larry Mann,Michael Sherman,Elizabeth Galbreath,Linda M. Schirtzinger,Darryl Ballard,Yun-Fei Chen,Philip W. Iversen,Beverly A. Teicher +8 more
TL;DR: Unexpected inhibition of PKCβ in vivo led to decreased VEGF production that persisted after therapy as well as to decreased intratumoral vessels.
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Vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating peptide receptor 2 deficiency in mice results in growth retardation and increased basal metabolic rate.
Mark A. Asnicar,Anja Köster,Mark L. Heiman,Frank C. Tinsley,Dennis P. Smith,Elizabeth Galbreath,Niles Fox,Yanfei Linda Ma,Werner F. Blum,Hansen M. Hsiung +9 more
TL;DR: The results suggest that VPAC2R plays an important role in growth, basal energy expenditure, and male reproductive functions.
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Use of tissue cross-reactivity studies in the development of antibody-based biopharmaceuticals: history, experience, methodology, and future directions.
Michael W. Leach,Wendy G. Halpern,Carol W. Johnson,Jennifer L. Rojko,Tim K. MacLachlan,Curtis M Chan,Elizabeth Galbreath,Anthony M. Ndifor,Diann Blanset,Evelyne Polack,Joy A. Cavagnaro +10 more
TL;DR: Tissue cross-reactivity studies are screening assays recommended for antibody and antibody-like molecules that contain a complementarity-determining region (CDR), primarily to identify off- target binding and, secondarily, to identify sites of on-target binding that were not previously identified.