J
Jesper Gromada
Researcher at Regeneron
Publications - 121
Citations - 10054
Jesper Gromada is an academic researcher from Regeneron. The author has contributed to research in topics: Glucagon & Glucagon receptor. The author has an hindex of 40, co-authored 120 publications receiving 8130 citations. Previous affiliations of Jesper Gromada include Novo Nordisk & Eli Lilly and Company.
Papers
More filters
Journal ArticleDOI
FGF-21 as a novel metabolic regulator
Alexei Kharitonenkov,Tatiyana L. Shiyanova,Anja Koester,Amy M. Ford,Radmila Micanovic,Elizabeth Galbreath,George E. Sandusky,Lisa Janine Hammond,Julie S. Moyers,Owens Rebecca Anne,Jesper Gromada,Joseph T. Brozinick,Eric D. Hawkins,Victor J. Wroblewski,De Shan Li,Farrokh Mehrbod,S. Richard Jaskunas,Armen B. Shanafelt +17 more
TL;DR: It is concluded that FGF-21, which was discovered to be a potent regulator of glucose uptake in mouse 3T3-L1 and primary human adipocytes, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
Journal ArticleDOI
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
Frederick E. Dewey,Viktoria Gusarova,Richard L Dunbar,Colm O'Dushlaine,Claudia Schurmann,Omri Gottesman,Shane McCarthy,Cristopher V. Van Hout,Shannon Bruse,Hayes Dansky,Joseph B. Leader,Michael F. Murray,Marylyn D. Ritchie,H. Lester Kirchner,Lukas Habegger,Alex Lopez,John Penn,An Zhao,Weiping Shao,Neil Stahl,Andrew J. Murphy,Sara Hamon,Aurelie Bouzelmat,Rick Zhang,Brad Shumel,Robert Pordy,Daniel A. Gipe,Gary Herman,Wayne H-H Sheu,I-Te Lee,I-Te Lee,Kae-Woei Liang,Kae-Woei Liang,Xiuqing Guo,Jerome I. Rotter,Yii-Der Ida Chen,William E. Kraus,Svati H. Shah,Scott M. Damrauer,Aeron Small,Daniel J. Rader,Anders Berg Wulff,Børge G. Nordestgaard,Anne Tybjærg-Hansen,Anita M. van den Hoek,Hans M.G. Princen,David H. Ledbetter,David J. Carey,John D. Overton,Jeffrey G. Reid,William J. Sasiela,Poulabi Banerjee,Alan R. Shuldiner,Ingrid B. Borecki,Tanya M. Teslovich,George D. Yancopoulos,Scott Mellis,Jesper Gromada,Aris Baras +58 more
TL;DR: Genetic and therapeutic antagonism of ANGPTL3 in humans and of Angptl3 in mice was associated with decreased levels of all three major lipid fractions and decreased odds of atherosclerotic cardiovascular disease.
Journal ArticleDOI
A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
Noura S. Abul-Husn,Xiping Cheng,Alexander H. Li,Yurong Xin,Claudia Schurmann,Panayiotis Stevis,Yashu Liu,Julia Kozlitina,Stefan Stender,G. Craig Wood,Ann Stepanchick,Matthew D. Still,Shane McCarthy,Colm O'Dushlaine,Jonathan S. Packer,Suganthi Balasubramanian,Nehal Gosalia,David Esopi,Sun Y. Kim,Semanti Mukherjee,Alexander E. Lopez,Erin D. Fuller,John Penn,Xin Chu,Jonathan Z. Luo,Uyenlinh L. Mirshahi,David J. Carey,Christopher D. Still,Michael Feldman,Aeron Small,Scott M. Damrauer,Daniel J. Rader,Brian Zambrowicz,William C. Olson,Andrew J. Murphy,Ingrid B. Borecki,Alan R. Shuldiner,Jeffrey G. Reid,John D. Overton,George D. Yancopoulos,Helen H. Hobbs,Jonathan C. Cohen,Omri Gottesman,Tanya M. Teslovich,Aris Baras,Tooraj Mirshahi,Jesper Gromada,Frederick E. Dewey +47 more
TL;DR: A loss‐of‐function variant in HSD17B13 was associated with a reduced risk of chronic liver disease and of progression from steatosis to steatohepatitis.
Journal ArticleDOI
Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways
Wolf Wente,Alexander M. Efanov,Martin B. Brenner,Alexei Kharitonenkov,Anja Köster,George E. Sandusky,Sabine Sewing,Iris Treinies,Heike Zitzer,Jesper Gromada +9 more
TL;DR: Preservation of β-cell function and survival by FGF-21 may contribute to the beneficial effects of this protein on glucose homeostasis observed in diabetic animals.
Journal ArticleDOI
RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes.
Yurong Xin,Jinrang Kim,Haruka Okamoto,Min Ni,Yi Wei,Christina Adler,Andrew J. Murphy,George D. Yancopoulos,Calvin Lin,Jesper Gromada +9 more
TL;DR: Single-cell RNA sequencing was used to determine the transcriptomes of 1,492 human pancreatic α, β, δ, and PP cells from non-diabetic and type 2 diabetes organ donors and identified cell-type-specific genes and pathways as well as 245 genes with disturbed expression intype 2 diabetes.