Elizabeth Groeber

TL;DR: The universality of the response of the Corona Charged Aerosol Detector (CoronaCAD) has been investigated under flow-injection and gradient HPLC elution conditions and a three-dimensional model was developed which relates the CoronaCAD response to analyte concentration and the mobile phase composition used.

TL;DR: It was found that these parameters exerted non-linear effects on the responses of the aerosol detectors and must therefore be considered when designing analytical separation conditions, particularly when gradient elution is performed.

TL;DR: In this article, an LC-MS/MS in combination with alumina-based solid phase extraction (SPE) was validated for the measurement of epinephrine and norepinephrine in human plasma with acceptable intra-day and inter-day accuracy and precision.

TL;DR: The chromatographic performance of fused-core (superficially porous) HPLC packing materials was compared with conventional fully porous particle materials for LC-MS/MS analysis of two pharmaceuticals in rat plasma to demonstrate reduced assay time and 2-3-fold increased efficiency.

TL;DR: It was found that whilst acetonitrile provided the highest column efficiencies and lowest detection limits of the solvents studied, acetone also performed well and could be used to resolve the same number of analytes as was possible with aconetitrile.