E
Elizabeth Pan
Researcher at Massachusetts Institute of Technology
Publications - 4
Citations - 3175
Elizabeth Pan is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene silencing & Cadherin. The author has an hindex of 4, co-authored 4 publications receiving 3042 citations.
Papers
More filters
Journal ArticleDOI
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
Li Ma,Jennifer J. Young,Harsha K. Prabhala,Elizabeth Pan,Pieter Mestdagh,Daniel Muth,Julie Teruya-Feldstein,Ferenc Reinhardt,Tamer T. Onder,Scott Valastyan,Frank Westermann,Frank Speleman,Jo Vandesompele,Robert A. Weinberg +13 more
TL;DR: It is shown that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased cell motility and invasiveness, and a regulatory and signalling pathway involving a metastasis-promoting miRNA that is predicted to directly target expression of the key metastasis
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
Li Ma,Jennifer J. Young,Harsha K. Prabhala,Elizabeth Pan,Pieter Mestdagh,Daniel Muth,Julie Teruya-Feldstein,Ferenc Reinhardt,Tamer T. Onder,Scott Valastyan,Frank Westermann,Frank Speleman,Jo Vandesompele,Robert A. Weinberg +13 more
TL;DR: In this article, the authors uncover a regulatory and signalling pathway involving a metastasis-promoting miRNA that is predicted to directly target expression of the key metastasissuppressing protein E-cadherin.
Journal ArticleDOI
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model
Li Ma,Ferenc Reinhardt,Elizabeth Pan,Jürgen Soutschek,Balkrishen Bhat,Eric G. Marcusson,Julie Teruya-Feldstein,George W. Bell,Robert A. Weinberg +8 more
TL;DR: In this paper, the authors show that systemic treatment of tumor-bearing mice with miR-10b antagomirs-a class of chemically modified anti-miRNA oligonucleotide-suppresses breast cancer metastasis.
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model
Ferenc Reinhardt,Elizabeth Pan,Jürgen Soutschek,Balkrishen Bhat,Eric G. Marcusson,Julie Teruya-Feldstein,George W. Bell,Li Ma,Robert A. Weinberg +8 more
TL;DR: It is shown that systemic treatment of tumor-bearing mice with miR-10b antagomirs—a class of chemically modified anti-miRNA oligonucleotide—suppresses breast cancer metastasis and appears to be a promising candidate for the development of new anti-metastasis agents.