E
Elizabeth Watson
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 4
Citations - 261
Elizabeth Watson is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Enteroendocrine cell & Gene expression. The author has an hindex of 4, co-authored 4 publications receiving 249 citations.
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Journal ArticleDOI
Processing, Distribution, and Function of VGF, a Neuronal and Endocrine Peptide Precursor
TL;DR: A nonredundant role of VGF products in the regulation of energy storage and expenditure is implied, implying a non redundant roles in theregulation of energystorage and expenditure.
Journal ArticleDOI
VGF Ablation Blocks the Development of Hyperinsulinemia and Hyperglycemia in Several Mouse Models of Obesity
Elizabeth Watson,Seung Hahm,Tooru M. Mizuno,Joan Windsor,Carla Montgomery,Philipp E. Scherer,Charles V. Mobbs,Stephen R.J. Salton +7 more
TL;DR: It is reported that VGF mutant mice have increased insulin sensitivity by hyperinsulinemic euglycemic clamp analysis, and by insulin and glucose tolerance testing, and that modulation of VGF levels and/or VGF signaling may represent an alternative means to regulate circulating glucose levels and insulin sensitivity.
Journal ArticleDOI
Analysis of knockout mice suggests a role for VGF in the control of fat storage and energy expenditure
Elizabeth Watson,Samira Fargali,Haruka Okamoto,Masato Sadahiro,Ronald E. Gordon,Tandra R. Chakraborty,Tandra R. Chakraborty,Mark W. Sleeman,Stephen R.J. Salton +8 more
TL;DR: It is proposed that VGF and/or VGF-derived peptides modulate sympathetic outflow pathways to regulate fat storage and energy expenditure and despite being hypermetabolic, VGF knockout mice were cold intolerant.
Journal ArticleDOI
Mining Microarrays for Metabolic Meaning: Nutritional Regulation of Hypothalamic Gene Expression
Charles V. Mobbs,Charles V. Mobbs,Kelvin Yen,Jason Mastaitis,Ha Nguyen,Elizabeth Watson,Elisa Wurmbach,Stuart C. Sealfon,Andrew I. Brooks,Stephen R.J. Salton,Stephen R.J. Salton +10 more
TL;DR: It is found that simply carrying out multiple t tests then sorting by P value constitutes a highly reliable method to detect true regulation, as assessed by real-time polymerase chain reaction (PCR), even for relatively low abundance genes or relatively low magnitude of regulation.