E
Ellen Van Obberghen-Schilling
Researcher at French Institute of Health and Medical Research
Publications - 50
Citations - 2822
Ellen Van Obberghen-Schilling is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Signal transduction & Extracellular matrix. The author has an hindex of 27, co-authored 50 publications receiving 2534 citations. Previous affiliations of Ellen Van Obberghen-Schilling include Centre national de la recherche scientifique & University of Nice Sophia Antipolis.
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Journal ArticleDOI
cDNA cloning and expression of a hamster α‐thrombin receptor coupled to Ca2+ mobilization
Ulla B. Rasmussen,Valérie Vouret-Craviari,Sophie Jallat,Yasmin Schlesinger,Gilles Pagès,Andrea Pavirani,Jean-Pierre Lecocq,Jacques Pouysségur,Ellen Van Obberghen-Schilling +8 more
TL;DR: To clone a thrombin receptor cDNA, selective amplification of mRNA sequences displaying homology to the transmembrane domains of G‐protein‐coupled receptor genes was performed by polymerase chain reaction.
Journal ArticleDOI
Regulation of the Actin Cytoskeleton by Thrombin in Human Endothelial Cells: Role of Rho Proteins in Endothelial Barrier Function
TL;DR: In this article, the authors examined the signal transduction pathways underlying agonist-stimulated reorganization of the actin cytoskeleton in human umbilical vein endothelial cells and found that Rho is involved in the maintenance of endothelial barrier function and Rac participates in cytoskeletal remodeling by thrombin.
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The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal.
Maude Le Gall,Jean-Claude Chambard,Jean-Philippe Breittmayer,Dominique Grall,Jacques Pouysségur,Ellen Van Obberghen-Schilling +5 more
TL;DR: The ability of p42/p44 mitogen-activated protein kinase to generate survival signals that counteract cell death induced by loss of matrix contact, cytoskeletal integrity, and extracellular mitogenic factors is highlighted.
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Transforming Growth Factor β Induces Rosettes of Podosomes in Primary Aortic Endothelial Cells
Christine Varon,Christine Varon,Florence Tatin,Florence Tatin,Violaine Moreau,Violaine Moreau,Ellen Van Obberghen-Schilling,Samantha Fernandez-Sauze,Edith Reuzeau,Edith Reuzeau,IJsbrand M. Kramer,IJsbrand M. Kramer,Elisabeth Génot,Elisabeth Génot +13 more
TL;DR: It is proposed that TGF-β plays an important role in endothelial cell physiology by inducing the formation of podosomal structures endowed with metalloprotease activity that may contribute to arterial remodeling.
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Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells.
TL;DR: The thrombin-induced contractile and immobile phenotype in endothelial cells reflects both robust RhoA activation and Rac inhibition, whereas Src- and Rac-dependent events couple sphingosine-1-phosphate receptors to the actin polymerizing machinery that drives the extension of lamellipodia and cell migration.