E
Ellen Vermeulen
Researcher at University of Amsterdam
Publications - 7
Citations - 1129
Ellen Vermeulen is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Antigen & Immunoglobulin G. The author has an hindex of 6, co-authored 7 publications receiving 1003 citations.
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Journal ArticleDOI
Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange
Marijn Van Der Neut Kolfschoten,Janine Schuurman,Mario Losen,Wim K. Bleeker,Pilar Martinez-Martinez,Ellen Vermeulen,Tamara H. den Bleker,Luus Wiegman,Tom Vink,Lucien A. Aarden,Marc H. De Baets,Marc H. De Baets,Jan G. J. van de Winkel,Jan G. J. van de Winkel,Rob C. Aalberse,Paul W. H. I. Parren +15 more
TL;DR: IgG4 Fab arm exchange is suggested to be an important biological mechanism that provides the basis for the anti-inflammatory activity attributed to IgG4 antibodies.
Journal ArticleDOI
Human IgG4 Binds to IgG4 and Conformationally Altered IgG1 via Fc-Fc Interactions
Theo Rispens,Pleuni Ooievaar-De Heer,Ellen Vermeulen,Janine Schuurman,Marijn Van Der Neut Kolfschoten,Rob C. Aalberse +5 more
TL;DR: It is proposed that the IgG4-IgG4 Fc interaction resembles an intermediate of the Fab-arm (half-molecule) exchange reaction that is stabilized because one of the Igg4 molecules is coupled to a solid phase.
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Phenotypic differences between IgG4+ and IgG1+ B cells point to distinct regulation of the IgG4 response.
Laura C. Lighaam,Ellen Vermeulen,Tamara H. den Bleker,Kimberley J. Meijlink,Rob C. Aalberse,Eleanor Barnes,Emma L. Culver,S. Marieke van Ham,Theo Rispens +8 more
Journal ArticleDOI
In vitro -Induced Human IL-10 + B Cells Do Not Show a Subset-Defining Marker Signature and Plastically Co-express IL-10 With Pro-Inflammatory Cytokines.
Laura C. Lighaam,Peter-Paul A. Unger,David W. Vredevoogd,Dorit Verhoeven,Ellen Vermeulen,Annelies W. Turksma,Anja ten Brinke,Theo Rispens,S. Marieke van Ham +8 more
TL;DR: Deep immune profiling by multicolor flow cytometry and t-SNE analysis shows that the majority of cells induced to produce IL-10 co-express pro-inflammatory cytokines IL-6 and/or TNFα, suggesting that in vitro-inducedIL-10 producing B cells are not a dedicated subset of regulatory B cells.
Journal ArticleDOI
Increased IgG4 responses to multiple food and animal antigens indicate a polyclonal expansion and differentiation of pre-existing B cells in IgG4-related disease
Emma L. Culver,Ellen Vermeulen,M Makuch,Astrid van Leeuwen,Ross Sadler,Tamsin Cargill,Paul Klenerman,Rob C. Aalberse,S. Marieke van Ham,Eleanor Barnes,Theo Rispens +10 more
TL;DR: This is the first study to show enhanced levels of polyclonal IgG4 to multiple antigens in Igg4-RD, which supports that elevated IgG 4 levels reflect an aberrant immunological regulation of the overall IgG3 response, but does not exclude that causality of disease could be antigen-driven.