A
Anja ten Brinke
Researcher at University of Amsterdam
Publications - 102
Citations - 2853
Anja ten Brinke is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Medicine & Cytotoxic T cell. The author has an hindex of 28, co-authored 77 publications receiving 2246 citations.
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Journal ArticleDOI
IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction--a comparative study of human clinical-applicable DC.
Martine A. Boks,Judith R. Kager-Groenland,Michiel S.P. Haasjes,Jaap Jan Zwaginga,Jaap Jan Zwaginga,S. Marieke van Ham,Anja ten Brinke +6 more
TL;DR: Clinical-grade IL-10 DC show functional characteristics that make them best suited for tolerance-inducing therapies, including migration and functional regulatory T cell induction.
Journal ArticleDOI
CD8⁺ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung.
Berber Piet,Godelieve J. de Bree,Barbara S. Smids-Dierdorp,Chris M. van der Loos,Ester B. M. Remmerswaal,Jan H. von der Thüsen,Jan M.W. van Haarst,J. P. Eerenberg,Anja ten Brinke,Wim van der Bij,Wim Timens,René A. W. van Lier,René E. Jonkers +12 more
TL;DR: The specificity and function of CD103⁺CD8⁺ T cells in protecting human lung against viral infection is determined and this mechanism may provide a rapid and efficient response to influenza infection, without inducing cytotoxic damage to the delicate epithelial barrier.
Journal ArticleDOI
Hurdles in therapy with regulatory T cells
Piotr Trzonkowski,Rosa Bacchetta,Manuela Battaglia,David Berglund,Hermann Bohnenkamp,Anja ten Brinke,Andrew Bushell,Nathalie Cools,Edward K. Geissler,Silvia Gregori,S. Marieke van Ham,Catharien M. U. Hilkens,James A. Hutchinson,Giovanna Lombardi,J. Alejandro Madrigal,Natalia Marek-Trzonkowska,Eva Martínez-Cáceres,Maria Grazia Roncarolo,Silvia Sánchez-Ramón,Aurore Saudemont,Birgit Sawitzki +20 more
TL;DR: The stance of the European Union Cooperation in Science and Technology Action BM1305, “Action to Focus and Accelerate Cell-based Tolerance-inducing Therapies—A FACTT,” is reported, which identifies hurdles hindering Treg clinical applications in Europe and provides possible solutions.
Journal ArticleDOI
A Genome-wide Multidimensional RNAi Screen Reveals Pathways Controlling MHC Class II Antigen Presentation
Petra Paul,Tineke van den Hoorn,Marlieke L.M. Jongsma,Mark J. Bakker,Rutger Hengeveld,Lennert Janssen,Peter Cresswell,David A. Egan,Marieke van Ham,Anja ten Brinke,Huib Ovaa,Roderick L. Beijersbergen,Coenraad Kuijl,Jacques Neefjes +13 more
TL;DR: A genome-wide flow cytometry-based RNAi screen detecting MHC-II expression and peptide loading followed by additional high-throughput assays have identified factors and pathways controlling M HC-II transcription and transport, defining targets for manipulation of MHC -II antigen presentation in infection and autoimmunity.
Journal ArticleDOI
The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants
Klaas P. J. M. van Gisbergen,Paul L. Klarenbeek,Natasja A. M. Kragten,Peter-Paul A. Unger,Marieke B. B. Nieuwenhuis,Felix M. Wensveen,Anja ten Brinke,Paul P. Tak,Eric Eldering,Martijn A. Nolte,René A. W. van Lier +10 more
TL;DR: It is proposed that CD27-driven costimulation is a strategy to generate memory clones that have potential reactivity to a wide array of mutable pathogens.