L
Lucien A. Aarden
Researcher at University of Amsterdam
Publications - 200
Citations - 19805
Lucien A. Aarden is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Antibody & T cell. The author has an hindex of 67, co-authored 200 publications receiving 19262 citations. Previous affiliations of Lucien A. Aarden include Chiron Corporation & Leiden University Medical Center.
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Journal ArticleDOI
Production of hybridoma growth factor by human monocytes.
TL;DR: Limiting dilution analysis of the producing cells in combination with size, density and adherence characteristics showed that HGF is produced by monocytes and not by lymphocytes, and there was no need for the monocytes to be stimulated but the cells did require the presence of serum.
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Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange
Marijn Van Der Neut Kolfschoten,Janine Schuurman,Mario Losen,Wim K. Bleeker,Pilar Martinez-Martinez,Ellen Vermeulen,Tamara H. den Bleker,Luus Wiegman,Tom Vink,Lucien A. Aarden,Marc H. De Baets,Marc H. De Baets,Jan G. J. van de Winkel,Jan G. J. van de Winkel,Rob C. Aalberse,Paul W. H. I. Parren +15 more
TL;DR: IgG4 Fab arm exchange is suggested to be an important biological mechanism that provides the basis for the anti-inflammatory activity attributed to IgG4 antibodies.
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Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways
TL;DR: The results show that in humans endotoxin induces an early, rapidly counteracted fibrinolytic response, and a more long-lasting activation of thrombin by a mechanism other than contact system activation, and suggest that endotoxin-induced leukopenia and endothelial cell activation are mediated by TNF.
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Increased plasma levels of interleukin-6 in sepsis.
C. E. Hack,E. de Groot,R. J. F. Felt-Bersma,J. H. Nuijens,R.J.M. Strack van Schijndel,A. J. M. Eerenberg-Belmer,L. G. Thijs,Lucien A. Aarden +7 more
TL;DR: Levels of IL-6 on admission appeared to be of prognostic significance: levels were higher in septic patients who subsequently died than in those who survived, in particular when only patients with septic shock were considered.
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Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.
TL;DR: The results suggest that the capacity of an antigen to induce PGE2 synthesis may play a crucial role in the development of either a Th1 or Th2 response.