Showing papers in "Immunity in 2004"

TL;DR: The full understanding of the immunobiology of cancer immunosurveillance and immunoediting will hopefully stimulate development of more effective immunotherapeutic approaches to control and/or eliminate human cancers.

TL;DR: Increasing evidence shows that IL-17 family members play an active role in inflammatory diseases, autoimmune diseases, and cancer, which places IL- 17 family members and their receptors as potential targets for future pharmacotherapy.

TL;DR: It is reported that NALP2 and NalP3 associate with ASC, the CARD-containing protein Cardinal, and caspase-1 (but not casp enzyme-5), thereby forming an inflammasome with high proIL-1beta-processing activity.

TL;DR: Vitamin A deficiency caused a reduction in alpha4beta7(+) memory/activated T cells in lymphoid organs and a depletion of T cells from the intestinal lamina propria, and revealed a novel role for retinoic acid in the imprinting of gut-homing specificity on T cells.

TL;DR: IL-22 does not serve the communication between immune cells but is a T cell mediator that directly promotes the innate, nonspecific immunity of tissues.

TL;DR: It is proposed that LAG-3 marks regulatory T cell populations and contributes to their suppressor activity, which reduces their proliferative capacity and confers on them suppressionor activity toward effector T cells.

TL;DR: It is demonstrated that activated human CD4(+)CD25(+) natural Treg cells express granzyme A but very little granzyme B, which suggests that the perforin/granzyme pathway is one of the mechanisms that T Reg cells can use to control immune responses.

TL;DR: The data identify CCR7 as a key regulator that governs trafficking of skin DC under both inflammatory and steady-state conditions and provides evidence that these cells represent a semimature population of DC that is capable of initiating T cell proliferation under conditions known to induce tolerance.

TL;DR: XBP1 coordinates diverse changes in cellular structure and function resulting in the characteristic phenotype of professional secretory cells, and upregulates genes encoding many secretory pathway components.

TL;DR: It is shown that, under conditions of dysregulated IL15 expression in vivo in patients with celiac disease and in vitro in healthy individuals, multiple steps of the NKG2D/DAP10 signaling pathway leading to ERK and JNK activation are coordinately primed to activate direct cytolytic function independent of TCR specificity in effector CD8 T cells.

TL;DR: The B lymphocyte characteristic location and movement between specific niches within bone marrow during development is demonstrated and it is suggested that CXCL12 maintains the cells in the niche.

TL;DR: It is concluded that the TLR9/MyD88 pathway mediates antiviral cytokine responses by IPC, DC, and possibly other cell types, which are coordinated to promote effective NK cell function and MCMV clearance.

TL;DR: Se sequencing of TRAV14 (Valpha2) TCRalpha chains associated with a transgenic TCRbeta chain finds that naturally arising TR have substantially more efficient interactions with MHC class II bound peptides from the peripheral self than CD25- T cells.

TL;DR: BAFF overexpression rescued only self-reactive B cells normally deleted with relatively low stringency and facilitated their migration into otherwise forbidden microenvironments, which is likely to underlie the autoimmunity associated with BAFF overeexpression.

TL;DR: This work shows that mice with a targeted deletion of T-bet have a profound, stem cell-intrinsic defect in their ability to generate mature NK and Valpha14i NKT cells.

TL;DR: It is shown that MICA is strongly expressed at epithelial cell surface in patients with active disease and is induced by gliadin or its p31-49 derived peptide upon in vitro challenge, which supports a key role for MIC/NKG2D in the activation of intraepithelial immunity in response to danger.

TL;DR: It is demonstrated that TGF-β signaling in tumor infiltrating T lymphocytes controls the growth of dysplastic epithelial cells in experimental colorectal cancer, as determined by histology and a novel system for high-resolution chromoendoscopy.

TL;DR: It is shown that alternative macrophages are essential during schistosomiasis for protection against organ injury through downregulation of egg-induced inflammation.

TL;DR: The advent of the zebrafish is discussed as a powerful vertebrate model organism that promises to positively impact immunologic research.

TL;DR: It is demonstrated that under conditions where BAFF levels are elevated, autoantigen-engaged cells will be rescued from rapid competitive elimination, predisposing to the development of autoimmune disease.

TL;DR: It is demonstrated that increased expression of Bmi-1 promotes HSC self-renewal and is a target for therapeutic manipulation of HSCs.

TL;DR: The identification of the LAGE1 protein as a ligand for tumor-specific CD4(+) Treg cell clones generated from the tumor-infiltrating lymphocytes (TILs) of cancer patients is reported, suggesting that the presence of tumor- specific Treg cells at tumor sites may have a profound effect on the inhibition of T cell responses against cancer.

TL;DR: Disruption of C/EBP alpha blocks the transition from the common myeloid to the granulocyte/monocyte progenitor but is not required beyond this stage for terminal granulocytes maturation, supporting the notion that disruption of EBP alpha cooperates with other events in the development of leukemia.

TL;DR: It is demonstrated that within minutes internalized TNF-R1 (TNF receptosomes) recruits TRADD, FADD, and caspase-8 to establish the "death-inducing signaling complex" (DISC) and identified the TNF -R1 internalization domain (TRID) required for receptor endocytosis.

TL;DR: It is shown that alternative macrophages are essential during schistosomiasis for protection against organ injury through downregulation of egg-induced inflammation.

TL;DR: A novel regulatory mechanism that specifically suppresses IL7Ralpha transcription in response to IL-7 and other prosurvival cytokines is described, suggesting that this homeostatic regulatory mechanism promotes survival of the maximum possible number of T cells for the amount ofIL-7 available.

TL;DR: It is found that the human neonatal Fc receptor (FcRn) is the vehicle that transports IgG across the intestinal epithelial barrier into the lumen where the IgG can bind cognate antigen.

TL;DR: Primary type 2 immune responses in the lung represent the focal recruitment and activation of discrete cell populations from the blood that have previously committed to express IL-4.

TL;DR: This work reconciles conflicting results from numerous groups by showing that multiple progenitors with a DN1 phenotype home to the thymus and make T cells, but possess different proliferative potentials and lineage capacities.

TL;DR: It is demonstrated that B1b lymphocytes can provide long-lasting T cell-independent IgM memory, and is found that mice deficient in T, follicular B, marginal zone B, or B1a lymphocytes resolved B. hersmii bacteremia and became resistant to reinfection.