E
Ellen Young
Researcher at University of North Carolina at Chapel Hill
Publications - 11
Citations - 486
Ellen Young is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Dengue virus & Epitope. The author has an hindex of 5, co-authored 10 publications receiving 411 citations.
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Journal ArticleDOI
Dengue Virus Envelope Dimer Epitope Monoclonal Antibodies Isolated from Dengue Patients Are Protective against Zika Virus
Jesica Swanstrom,Jessica A. Plante,Kenneth S. Plante,Ellen Young,Eileen McGowan,Emily N. Gallichotte,Douglas G. Widman,Mark T. Heise,A. M. de Silva,Ralph S. Baric +9 more
TL;DR: The availability of potently neutralizing human monoclonal antibodies provides an immunotherapeutic approach to control life-threatening ZIKV infection and also points to the possibility of repurposing DENV vaccines to induce cross-protective immunity to ZikV.
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Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection.
Matthew H. Collins,Eileen McGowan,Ramesh Jadi,Ellen Young,Cesar A. Lopez,Ralph S. Baric,Helen M. Lazear,Aravinda M. de Silva +7 more
TL;DR: The data suggest that most DENV infections do not induce durable, high-level Zika virus cross-neutralizing antibodies, and that Zika virus–specific antibody populations develop after Zika virus infection irrespective of prior DENV immunity.
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A Reverse Genetics Platform That Spans the Zika Virus Family Tree
Douglas G. Widman,Ellen Young,Boyd Yount,Kenneth S. Plante,Emily N. Gallichotte,Derek L. Carbaugh,Kayla M. Peck,Jessica A. Plante,Jesica Swanstrom,Mark T. Heise,Helen M. Lazear,Ralph S. Baric +11 more
TL;DR: A panel of molecular clones and recombinant virus isolates will enable targeted studies of viral determinants of pathogenesis, adaptation, and evolution, as well as the rational attenuation of contemporary outbreak strains to facilitate the design of vaccines and therapeutics.
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Transplantation of a quaternary structure neutralizing antibody epitope from dengue virus serotype 3 into serotype 4.
Douglas G. Widman,Ellen Young,Usha K. Nivarthi,Jesica Swanstrom,Scott R. Royal,Boyd Yount,Kari Debbink,Kari Debbink,Matthew Begley,Stephanie Marcet,Anna P. Durbin,Aravinda M. de Silva,William B. Messer,William B. Messer,Ralph S. Baric +14 more
TL;DR: It is concluded that the hinge-spanning region of the 5J7 quaternary epitope is a target for serotype-specific neutralizing antibodies after DENV3 infection.
Journal ArticleDOI
Identification of Dengue Virus Serotype 3 Specific Antigenic Sites Targeted by Neutralizing Human Antibodies
Ellen Young,Robert H. Carnahan,Daniela V. Andrade,Nurgun Kose,Rachel S. Nargi,Ethan J. Fritch,Jennifer E. Munt,Michael P. Doyle,Laura J. White,Thomas J. Baric,Mark Stoops,Aravinda Desilva,Longping V. Tse,David R. Martinez,Deanna Zhu,Stefan W. Metz,Marcus P Wong,Diego A. Espinosa,Magelda Montoya,Scott B. Biering,Soila Sukulpolvi-Petty,Guillermina Kuan,Angel Balmaseda,Michael S. Diamond,Eva Harris,James E. Crowe,Ralph S. Baric +26 more
TL;DR: Investigation of the human B cell response in children after natural DENV infection in the endemic area of Nicaragua and isolated 15 DENV3 TS mAbs recognizing the envelope (E) glycoprotein revealed a complex landscape with protective epitopes clustering in at least 6-7 antigenic sites.