D
Diego A. Espinosa
Researcher at University of California, Berkeley
Publications - 45
Citations - 2530
Diego A. Espinosa is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Circumsporozoite protein & Plasmodium falciparum. The author has an hindex of 24, co-authored 44 publications receiving 2064 citations. Previous affiliations of Diego A. Espinosa include Instituto de Medicina Tropical Alexander von Humboldt & Cayetano Heredia University.
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Journal ArticleDOI
Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
Karin Stettler,Martina Beltramello,Diego A. Espinosa,Victoria A. Graham,Antonino Cassotta,Antonino Cassotta,Siro Bianchi,Fabrizia Vanzetta,Andrea Minola,Stefano Jaconi,Federico Mele,Mathilde Foglierini,Mattia Pedotti,Luca Simonelli,Stuart D. Dowall,Barry Atkinson,Elena Percivalle,Cameron P. Simmons,Cameron P. Simmons,Luca Varani,Johannes Blum,Johannes Blum,Fausto Baldanti,Elisabetta Cameroni,Roger Hewson,Eva Harris,Antonio Lanzavecchia,Antonio Lanzavecchia,Federica Sallusto,Davide Corti +29 more
TL;DR: The most potent neutralizing antibodies were ZIKV-specific and targeted EDIII or quaternary epitopes on infectious virus, and an EDIII-targeted antibody protected mice against lethal infection, illustrating the potential for antibody-based therapy.
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Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism
Henry Puerta-Guardo,Dustin R. Glasner,Diego A. Espinosa,Scott B. Biering,Mark Patana,Kalani Ratnasiri,Chunling Wang,P. Robert Beatty,Eva Harris +8 more
TL;DR: It is demonstrated that NS1 from dengue, Zika, West Nile, Japanese encephalitis, and yellow fever viruses selectively binds to and alters permeability of human endothelial cells from lung, dermis, umbilical vein, brain, and liver in vitro and causes tissue-specific vascular leakage in mice, reflecting the pathophysiology of each flavivirus.
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The Chemokine Receptor CXCR6 Is Required for the Maintenance of Liver Memory CD8+ T Cells Specific for Infectious Pathogens
TL;DR: These studies are the first to show that CXCR6 is critical for the development and maintenance of protective memory CD8(+) T cells in the liver.
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Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components
Dustin R. Glasner,Kalani Ratnasiri,Henry Puerta-Guardo,Diego A. Espinosa,P. Robert Beatty,Eva Harris +5 more
TL;DR: Data indicate that DENV NS1-induced endothelial cell-intrinsic vascular leak is independent of inflammatory cytokines but dependent on endothelial glycocalyx components.
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A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential
Jiaqi Wang,Marco Bardelli,Diego A. Espinosa,Mattia Pedotti,T.S. Ng,Siro Bianchi,Luca Simonelli,Elisa X.Y. Lim,Mathilde Foglierini,Fabrizia Zatta,Stefano Jaconi,Martina Beltramello,Elisabetta Cameroni,Guntur Fibriansah,Jian Shi,Taylor Barca,Isabel Pagani,Alicia Rubio,Vania Broccoli,Elisa Vicenzi,Victoria A. Graham,Steven T. Pullan,Stuart D. Dowall,Roger Hewson,Simon Jurt,Oliver Zerbe,Karin Stettler,Antonio Lanzavecchia,Federica Sallusto,Andrea Cavalli,Eva Harris,Shee-Mei Lok,Luca Varani,Davide Corti +33 more
TL;DR: A bispecific antibody comprising ZKA190 and a second mAb specific for DII of E protein, FIT-1 robustly prevented viral escape, warranting its development as a ZIKV immunotherapy.