M
Matthew H. Collins
Researcher at Emory University
Publications - 65
Citations - 2632
Matthew H. Collins is an academic researcher from Emory University. The author has contributed to research in topics: Zika virus & Medicine. The author has an hindex of 20, co-authored 50 publications receiving 1740 citations. Previous affiliations of Matthew H. Collins include University of North Carolina at Chapel Hill & Georgia Regents University.
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Journal ArticleDOI
The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients.
Lakshmanane Premkumar,Bruno Segovia-Chumbez,Ramesh Jadi,David R. Martinez,Rajendra Raut,Alena J. Markmann,Caleb Cornaby,Luther A. Bartelt,Susan R. Weiss,Yara A. Park,Caitlin E. Edwards,Eric T. Weimer,Erin M. Scherer,Nadine Rouphael,Srilatha Edupuganti,Daniela Weiskopf,Longping V. Tse,Yixuan J. Hou,David M. Margolis,Alessandro Sette,Alessandro Sette,Matthew H. Collins,John L. Schmitz,Ralph S. Baric,Aravinda M. de Silva +24 more
TL;DR: Results, which reveal the early kinetics of Sars-CoV-2 antibody responses, support using the RBD antigen in serological diagnostic assays and RBD-specific antibody levels as a correlate of SARS-Co V-2 neutralizing antibodies in people.
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CD8+ T-Cell Responses to Trypanosoma cruzi Are Highly Focused on Strain-Variant trans-Sialidase Epitopes
Diana L. Martin,D. Brent Weatherly,Susana A. Laucella,Melissa A Cabinian,Matthew T Crim,Susan Sullivan,Mark Heiges,Sarah H Craven,Charles S. Rosenberg,Matthew H. Collins,Alessandro Sette,Miriam Postan,Rick L. Tarleton +12 more
TL;DR: It is demonstrated that in both hosts the CD8+ T-cell response is highly focused on epitopes encoded by members of the large trans-sialidase family of genes, suggesting that immune evasion may be occurring at a population rather than single-parasite level.
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COVID-19 serology at population scale: SARS-CoV-2-specific antibody responses in saliva.
Nora Pisanic,Pranay R. Randad,Kate Kruczynski,Yukari C. Manabe,David L. Thomas,Andrew Pekosz,Sabra L. Klein,Michael J. Betenbaugh,William Clarke,Oliver Laeyendecker,Oliver Laeyendecker,Patrizio Caturegli,H. Benjamin Larman,Barbara Detrick,Jessica K. Fairley,Amy C Sherman,Nadine Rouphael,Srilatha Edupuganti,Douglas A. Granger,Steve W. Granger,Matthew H. Collins,Christopher D. Heaney +21 more
TL;DR: Algorithms employing a combination of the IgG responses to N and S antigens result in high diagnostic accuracy by as early as 10 DPSO, and support the use of saliva-based antibody testing as a noninvasive and scalable alternative to blood- based antibody testing.
Journal ArticleDOI
Prior Dengue Virus Exposure Shapes T Cell Immunity to Zika Virus in Humans.
Alba Grifoni,John Pham,John Sidney,Patrick H. O'Rourke,Sinu Paul,Bjoern Peters,Sheridan Martini,Aruna D. De Silva,Aruna D. De Silva,Michael J. Ricciardi,Diogo M. Magnani,Cassia G. T. Silveira,Alvino Maestri,Priscilla R. Costa,Luzia Maria de-Oliveira-Pinto,Elzinandes Leal de Azeredo,Paulo Vieira Damasco,Elizabeth J. Phillips,Elizabeth J. Phillips,Simon Mallal,Simon Mallal,Aravinda M. de Silva,Matthew H. Collins,Anna P. Durbin,Sean A. Diehl,Cristhiam Cerpas,Angel Balmaseda,Guillermina Kuan,Josefina Coloma,Eva Harris,James E. Crowe,Mars Stone,Phillip J. Norris,Michael P. Busch,Héctor Vivanco-Cid,Josephine Cox,Barney S. Graham,Julie E. Ledgerwood,Lance Turtle,Lance Turtle,Tom Solomon,Tom Solomon,Esper G. Kallas,David I. Watkins,Daniela Weiskopf,Alessandro Sette +45 more
TL;DR: The kinetics and viral epitopes targeted by T cells responding to ZIKV and whether preexisting dengue virus (DENV) T cell immunity modulates these responses are investigated and it is found that memory T cell responses elicited by prior infection with DENV or vaccination with tetravalent d Dengue attenuated vaccines (TDLAV) recognize ZikV-derived peptides.
Journal ArticleDOI
Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection.
Matthew H. Collins,Eileen McGowan,Ramesh Jadi,Ellen Young,Cesar A. Lopez,Ralph S. Baric,Helen M. Lazear,Aravinda M. de Silva +7 more
TL;DR: The data suggest that most DENV infections do not induce durable, high-level Zika virus cross-neutralizing antibodies, and that Zika virus–specific antibody populations develop after Zika virus infection irrespective of prior DENV immunity.