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Els Keyaerts
Researcher at Katholieke Universiteit Leuven
Publications - 58
Citations - 3150
Els Keyaerts is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Coronavirus & Virus. The author has an hindex of 21, co-authored 52 publications receiving 2611 citations. Previous affiliations of Els Keyaerts include Rega Institute for Medical Research.
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In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine
TL;DR: Chloroquine, an old antimalarial drug, may be considered for immediate use in the prevention and treatment of SARS-CoV infections.
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Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event.
Leen Vijgen,Els Keyaerts,Elien Moës,Inge Thoelen,Elke Wollants,Philippe Lemey,Anne-Mieke Vandamme,Marc Van Ranst +7 more
TL;DR: This is the first animal-human zoonotic pair of coronaviruses that can be analyzed in order to gain insights into the processes of adaptation of a nonhuman coronavirus to a human host, which is important for understanding the interspecies transmission events that led to the origin of the severe acute respiratory syndrome outbreak.
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Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle.
Els Keyaerts,Leen Vijgen,Christophe Pannecouque,Els J.M. Van Damme,Willy J. Peumans,Herman Egberink,Jan Balzarini,Marc Van Ranst +7 more
TL;DR: The antiviral activity of plant lectins with specificity for different glycan structures against the severe acute respiratory syndrome coronavirus (SARS-CoV) and the feline infectious peritonitis virus (FIPV) in vitro is described.
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Antiviral Activity of Chloroquine against Human Coronavirus OC43 Infection in Newborn Mice
TL;DR: It is demonstrated that chloroquine, a widely used drug with well-known antimalarial effects, inhibits HCoV-OC43 replication in HRT-18 cells and may be considered as a future drug against HCoVs.
Journal ArticleDOI
Evolutionary History of the Closely Related Group 2 Coronaviruses: Porcine Hemagglutinating Encephalomyelitis Virus, Bovine Coronavirus, and Human Coronavirus OC43
Leen Vijgen,Els Keyaerts,Philippe Lemey,Piet Maes,Kristien Van Reeth,Hans Nauwynck,Maurice Pensaert,Marc Van Ranst +7 more
TL;DR: This study determined the complete genomic sequence of PHEV (strain PHEV-VW572), revealing the presence of a truncated group 2-specific ns2 gene in PHEV in comparison to other group 2 coronaviruses.