Els Torreele

TL;DR: It is found that, of 1393 new chemical entities marketed between 1975 and 1999, only 16 were for tropical diseases and tuberculosis, and there is a 13-fold greater chance of a drug being brought to market for central-nervous-system disorders or cancer than for a neglected disease.

TL;DR: The efficacy of NECT is non-inferior to that of eflornithine monotherapy, which is suitable for first-line use in HAT control programmes and potentially protective against the emergence of resistant parasites.

TL;DR: A group of respected global health practitioners reflecting on lessons learned from the Ebola outbreak describe some of the major threats to individual and collective human health, as well as the values and recommendations that should be considered to counteract such threats in the future.

TL;DR: Fexinidazole is shown to be a short-course, safe and effective oral treatment curing both acute and chronic HAT and that could be implemented at the primary health care level and the results of the preclinical pharmacological and safety studies indicate that fexinidrazole is a safe andeffective oral drug candidate with no untoward effects that would preclude evaluation in man.

TL;DR: One of the critical issues to be discussed at the next World Health Assembly will be a resolution about a global framework on essential health research and development, which is clearly shown by the number of drugs targeting neglected tropical diseases.