http://www.chtf.stuba.sk/~szolcsanyi/education/files/Chemia%20heterocyklickych%20zlucenin/Prednaska%202/Doplnkove%20studijne%20materialy/Indole/Biological%20Importance%20of%20the%20Indole%20Nucleus%20in%20Recent%20Years%20-%20A%20Comprehensive%20Review.pdf

Biological importance of the indole nucleus in recent years: A comprehensive review

Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.

1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry

Indoles - A promising scaffold for drug development.

Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.

Synthesis, anti-HCV, antioxidant, and peroxynitrite inhibitory activity of fused benzosuberone derivatives.

A convenient synthesis of a series of thiosemicarbazide, 1,3,4-oxadiazole, 1,3,4-thiadiazole, thiazole, 1,2,4-triazole, pyrazole and dioxoisoindoline derivatives incorporating 1,2,4-triazolo[4,3-a]pyrimidine via the reaction of the readily accessible 1,5-dihydro-5-oxo-1.7-diphenyl-1,2.4-triazolo[4,3-a]pyrimidine-3-carbohydrazide (2) with the appropriate reagents is described. The newly synthesized compounds were found to possess antihypertensive and diuretic activities compared to captopril and furosemide as reference controls, respectively.

/pdf/synthesis-of-new-functionalized-3-substituted-1-2-4-triazolo-3ttywx9sj2.pdf

Synthesis of new functionalized 3-substituted [1,2,4]triazolo [4,3-a]pyrimidine derivatives: potential antihypertensive agents.

Background Exposure to lead (Pb) has been associated with endocrine, hematological, gastrointestinal, renal and neurological problems in humans However, effects on the thyroid gland are controver

/pdf/assessment-of-thyroid-function-and-oxidative-stress-state-in-5ebr9p3q4k.pdf

Assessment of Thyroid Function and Oxidative Stress State in Foundry Workers Exposed to Lead

Biotic changes and a salinity increase (from 13 to 40 g.L-1 ) occurred in Lake Qarun (Egypt) since 1901. Was salinity increasing a cause of observed biotic changes? To answer this question we used benthos as a model group. Benthos and water sampling was conducted in different seasons (2008–2013). Comparing our and literature data, we discuss the long-term trends and possible causes of benthos changes. Salinity reached 3 g.L-1 in middle of 19th century; and biotic changes caused by this were started. From middle 19th century to 1928 a biotic transformation was driven by the salinity increase; after 1928 a regular alien species introduction caused that a marine community formed. In 1970–2000 eutrophication played a main role in species composition changes. In 2014 ctenophore Mnemiopsis leidyi introduced in the lake; eutrophication, chemical pollution, and a population dynamics of this ctenophore may be main drivers of the ecosystem change now. Benthos biomass gradually decreased during interval 1975–2013 without any correlation with salinity change. A variety of other factors than salinity may be significant in determining the structure and dynamics of communities, and we conclude that we have a small chance to make a correct forecast of possible future ecosystem changes in Lake Qarun.

/pdf/long-term-changes-of-physicochemical-parameters-and-benthos-2gh0uw8f2b.pdf

Eman A. Ragab

Papers

Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.

Synthesis, anti-HCV, antioxidant, and peroxynitrite inhibitory activity of fused benzosuberone derivatives.

Synthesis of new functionalized 3-substituted [1,2,4]triazolo [4,3-a]pyrimidine derivatives: potential antihypertensive agents.

Assessment of Thyroid Function and Oxidative Stress State in Foundry Workers Exposed to Lead

Long-term changes of physicochemical parameters and benthos in Lake Qarun (Egypt): Can we make a correct forecast of ecosystem future?