Journal ArticleDOI
Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
TLDR
The newly synthesized compounds were found to possess potential anti-inflammatory and analgesic activities and to be compatible with existing thiazolidin-4-one derivatives.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2007-06-01. It has received 233 citations till now. The article focuses on the topics: Indole test.read more
Citations
More filters
Journal ArticleDOI
Biological importance of the indole nucleus in recent years: A comprehensive review
TL;DR: Indole has a benzene ring and pyrrole ring sharing one double bond and is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom as mentioned in this paper.
Journal ArticleDOI
Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.
Navriti Chadha,Om Silakari +1 more
TL;DR: An overview of the chemistry, biology, and toxicology of indoles focusing on their application as drugs is provided to corroborate the information available on the natural indole alkaloids, indole based FDA approved drugs and clinical trial candidates having diverse therapeutic implementations.
Journal ArticleDOI
1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry
Journal ArticleDOI
Indoles - A promising scaffold for drug development.
T.V. Sravanthi,S. L. Manju +1 more
TL;DR: A clear knowledge is provided on the wide-ranging biological activities of 2-arylindoles over the past two decades, which would be beneficial for the designing of more potent drug targets in order to compete with the existing drugs.
Journal ArticleDOI
Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
TL;DR: A detailed account of the design strategies employed for the synthesis of anticancer agents via molecular hybridization techniques is offered and the structure activity relationship along with mechanistic insights revealed during the biological evaluation of the hybrids are highlighted.
References
More filters
Journal ArticleDOI
Goodman and Gilman's the Pharmacological Basis of Therapeutics
William H. Stigelman,Pharm D. +1 more
Journal Article
Synthetic analgesics. ii. dithienylbutenyl- and dithienylbutylamines
Book
Evaluation of Drug Activities: Pharmacometrics
D. R. Laurence,A. L. Bacharach +1 more
TL;DR: This guide for practising pharmacologists should also enable biochemists, physiologists and others to perform pharmacometric evaluations of which they have had no previous experience.
Journal ArticleDOI
Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory-antimicrobial agents
TL;DR: Compounds 4 and 12a are the most distinctive derivatives identified in the present study because of their remarkable in vivo and in vitro anti-inflammatory potency and their pronounced antibacterial activities comparable to ampicillin against Gram positive.