E
Emily L. Paterson
Researcher at University of Adelaide
Publications - 5
Citations - 3873
Emily L. Paterson is an academic researcher from University of Adelaide. The author has contributed to research in topics: Cancer & microRNA. The author has an hindex of 3, co-authored 4 publications receiving 3617 citations. Previous affiliations of Emily L. Paterson include South Australia Pathology.
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Journal ArticleDOI
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
Philip A. Gregory,Andrew G. Bert,Emily L. Paterson,Simon C. Barry,Anna Tsykin,Gelareh Farshid,Mathew A. Vadas,Mathew A. Vadas,Yeesim Khew-Goodall,Gregory J. Goodall +9 more
TL;DR: It is found that all five members of the microRNA-200 family were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-β or to ectopic expression of the protein tyrosine phosphatase Pez, suggesting that downregulation of themicroRNAs may be an important step in tumour progression.
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Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression.
Emily L. Paterson,Emily L. Paterson,Jan Kazenwadel,Andrew G. Bert,Yeesim Khew-Goodall,Yeesim Khew-Goodall,Andrew Ruszkiewicz,Gregory J. Goodall,Gregory J. Goodall +8 more
TL;DR: Data support the involvement of EMT and mesenchymal-to-epithelial transition (MET) in the metastasis cascade and show that miR-200 is downregulated in the initial stages of stromal invasion but is restored at metastatic sites.
Journal ArticleDOI
The microRNA-200 Family Regulates Epithelial to Mesenchymal Transition
Emily L. Paterson,Natasha Kolesnikoff,Philip A. Gregory,Andrew G. Bert,Yeesim Khew-Goodall,Gregory J. Goodall +5 more
TL;DR: Epithelial-mesenchymal transition is implicated in metastasis initiation and has recently been shown to be regulated by the miRNA-200 family and miR-205, suggesting these microRNAs may play a role in cancer metastasis.
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Recommendations for extracellular vesicle miRNA biomarker research in the endometrial cancer context
TL;DR: Extracellular vesicles (EVs) are membrane-bound particles present in bodily fluids that have the potential to facilitate non-invasive, early diagnosis of endometrial cancer and could aid with monitoring of recurrence and treatment response as mentioned in this paper .