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Yeesim Khew-Goodall
Researcher at University of South Australia
Publications - 44
Citations - 8035
Yeesim Khew-Goodall is an academic researcher from University of South Australia. The author has contributed to research in topics: Epithelial–mesenchymal transition & Cancer. The author has an hindex of 27, co-authored 43 publications receiving 6931 citations. Previous affiliations of Yeesim Khew-Goodall include University of Adelaide & South Australia Pathology.
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Journal ArticleDOI
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
Philip A. Gregory,Andrew G. Bert,Emily L. Paterson,Simon C. Barry,Anna Tsykin,Gelareh Farshid,Mathew A. Vadas,Mathew A. Vadas,Yeesim Khew-Goodall,Gregory J. Goodall +9 more
TL;DR: It is found that all five members of the microRNA-200 family were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-β or to ectopic expression of the protein tyrosine phosphatase Pez, suggesting that downregulation of themicroRNAs may be an important step in tumour progression.
Journal ArticleDOI
Guidelines and definitions for research on epithelial–mesenchymal transition
Jing Yang,Parker B. Antin,Geert Berx,Cédric Blanpain,Thomas Brabletz,Marianne E. Bronner,Kyra Campbell,Amparo Cano,Jordi Casanova,Gerhard Christofori,Shoukat Dedhar,Rik Derynck,Heide L. Ford,Jonas Fuxe,Antonio García de Herreros,Gregory J. Goodall,Anna-Katerina Hadjantonakis,Ruby Yun-Ju Huang,Chaya Kalcheim,Raghu Kalluri,Yibin Kang,Yeesim Khew-Goodall,Herbert Levine,Jinsong Liu,Gregory D. Longmore,Sendurai A. Mani,Joan Massagué,Roberto Mayor,David R. McClay,Keith E. Mostov,Donald F. Newgreen,M. Angela Nieto,Alain Puisieux,Alain Puisieux,Raymond B. Runyan,Pierre Savagner,Ben Z. Stanger,Marc P. Stemmler,Yoshiko Takahashi,Masatoshi Takeichi,Eric Theveneau,Jean Paul Thiery,Erik W. Thompson,Robert A. Weinberg,Elizabeth D. Williams,Jianhua Xing,Binhua P. Zhou,Guojun Sheng +47 more
TL;DR: This Consensus Statement is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications to reduce misunderstanding and misinterpretation of research data generated in various experimental models.
Journal ArticleDOI
An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
Philip A. Gregory,Cameron P. Bracken,Cameron P. Bracken,Eric Smith,Andrew G. Bert,Josephine A. Wright,Josephine A. Wright,Suraya Roslan,Melanie Morris,Leila Wyatt,Leila Wyatt,Gelareh Farshid,Yat-Yuen Lim,Yat-Yuen Lim,Yat-Yuen Lim,Geoffrey J. Lindeman,M. Frances Shannon,Paul A. Drew,Yeesim Khew-Goodall,Yeesim Khew-Goodall,Gregory J. Goodall,Gregory J. Goodall +21 more
TL;DR: A signaling network involving autocrine TGF-β signaling, ZEB transcription factors, and the miR-200 family regulates interconversion between epithelial and mesenchymal states.
Journal ArticleDOI
Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway.
Pu Xia,Jennifer R. Gamble,Kerry-Anne Rye,Lijun Wang,Charles S. T. Hii,Peter N. Cockerill,Yeesim Khew-Goodall,Andrew G. Bert,Philip J. Barter,Mathew A. Vadas +9 more
TL;DR: It is demonstrated that the SKase pathway through the generation of S1P is critically involved in mediating TNFalpha-induced endothelial cell activation.
Journal Article
Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells.
TL;DR: Perivascular TGF-beta appears to act as an inhibitor of the expression of the endothelium-specific selectin, E-selectin, and therefore of inflammatory responses involving neutrophils and (a subset of) lymphocytes.