P
Philip A. Gregory
Researcher at University of South Australia
Publications - 60
Citations - 10594
Philip A. Gregory is an academic researcher from University of South Australia. The author has contributed to research in topics: Epithelial–mesenchymal transition & microRNA. The author has an hindex of 31, co-authored 55 publications receiving 9462 citations. Previous affiliations of Philip A. Gregory include Flinders Medical Centre & Flinders University.
Papers
More filters
Journal ArticleDOI
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.
Philip A. Gregory,Andrew G. Bert,Emily L. Paterson,Simon C. Barry,Anna Tsykin,Gelareh Farshid,Mathew A. Vadas,Mathew A. Vadas,Yeesim Khew-Goodall,Gregory J. Goodall +9 more
TL;DR: It is found that all five members of the microRNA-200 family were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-β or to ectopic expression of the protein tyrosine phosphatase Pez, suggesting that downregulation of themicroRNAs may be an important step in tumour progression.
Journal ArticleDOI
The RNA binding protein quaking regulates formation of circRNAs.
Simon J. Conn,Katherine A. Pillman,Katherine A. Pillman,John Toubia,John Toubia,Vanessa M. Conn,Marika Salmanidis,Caroline A Phillips,Caroline A Phillips,Suraya Roslan,Andreas W. Schreiber,Andreas W. Schreiber,Andreas W. Schreiber,Philip A. Gregory,Philip A. Gregory,Gregory J. Goodall,Gregory J. Goodall +16 more
TL;DR: It is shown that hundreds of circRNAs are regulated during human epithelial-mesenchymal transition (EMT) and that the production of over one-third of abundant circ RNAs is dynamically regulated by the alternative splicing factor, Quaking (QKI), which itself is regulated during EMT.
Journal ArticleDOI
A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition
Cameron P. Bracken,Philip A. Gregory,Natasha Kolesnikoff,Andrew G. Bert,Jun Wang,M. Frances Shannon,Gregory J. Goodall +6 more
TL;DR: A double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype is established and has direct relevance to the role of these factors in tumor progression.
Journal ArticleDOI
An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
Philip A. Gregory,Cameron P. Bracken,Cameron P. Bracken,Eric Smith,Andrew G. Bert,Josephine A. Wright,Josephine A. Wright,Suraya Roslan,Melanie Morris,Leila Wyatt,Leila Wyatt,Gelareh Farshid,Yat-Yuen Lim,Yat-Yuen Lim,Yat-Yuen Lim,Geoffrey J. Lindeman,M. Frances Shannon,Paul A. Drew,Yeesim Khew-Goodall,Yeesim Khew-Goodall,Gregory J. Goodall,Gregory J. Goodall +21 more
TL;DR: A signaling network involving autocrine TGF-β signaling, ZEB transcription factors, and the miR-200 family regulates interconversion between epithelial and mesenchymal states.
Journal ArticleDOI
MicroRNAs as regulators of epithelial-mesenchymal transition
TL;DR: A review of recent findings and their implications in both developmental EMT and tumor progression describes the molecular reprogramming and phenotypic changes involved in the conversion of polarised immotile epithelial cells to motile mesenchymal cells.