Emily R. Rosario

TL;DR: Data indicate JNK mediates Aβ oligomer inactivation of IRS-1 and phospho-tau pathology and that dietary treatment with fish oil/DHA, curcumin, or a combination of both has the potential to improve insulin/trophic signaling and cognitive deficits in AD.

TL;DR: The successful use of hormone therapies in aging men and women to delay, prevent, and or treat AD will require additional research to optimize key parameters of hormone therapy and may benefit from the continuing development of selective estrogen and androgen receptor modulators.

TL;DR: It is demonstrated that estrogen and progesterone independently and interactively regulate AD-like neuropathology and suggest that an optimized hormone therapy may be useful in reducing the risk of AD in postmenopausal women.

TL;DR: Sex-specific relationships between normal, age-related depletion of androgens and estrogens in men and women, which may be relevant to development of AD, are demonstrated.

TL;DR: Compared progression of β-amyloid pathology in male and female triple transgenic mice is compared to demonstrate significant sex differences in pathology in 3xTg-AD mice and suggest that these differences may be mediated by organizational actions of sex steroid hormones during development.