O
Oliver J. Ubeda
Researcher at University of California, Los Angeles
Publications - 27
Citations - 7103
Oliver J. Ubeda is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Docosahexaenoic acid & Alzheimer's disease. The author has an hindex of 18, co-authored 27 publications receiving 6656 citations. Previous affiliations of Oliver J. Ubeda include Veterans Health Administration.
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Journal ArticleDOI
Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo
Fusheng Yang,Giselle P. Lim,Giselle P. Lim,Aynun N. Begum,Aynun N. Begum,Oliver J. Ubeda,Oliver J. Ubeda,Mychica Simmons,Mychica Simmons,Surendra S. Ambegaokar,Surendra S. Ambegaokar,Pingping P. Chen,Pingping P. Chen,Rakez Kayed,Charles G. Glabe,Sally A. Frautschy,Sally A. Frautschy,Gregory M. Cole,Gregory M. Cole +18 more
TL;DR: It is suggested that low dose curcumin effectively disaggregates Aβ as well as prevents fibril and oligomer formation, supporting the rationale forCurcumin use in clinical trials preventing or treating AD.
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Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease
Giselle P. Lim,Giselle P. Lim,Fusheng Yang,Fusheng Yang,T. Chu,T. Chu,Patrick B. Chen,Patrick B. Chen,Walter Beech,Walter Beech,Bruce Teter,Bruce Teter,Tracy S. Tran,Tracy S. Tran,Oliver J. Ubeda,Oliver J. Ubeda,K. Hsiao Ashe,Sally A. Frautschy,Greg M. Cole +18 more
TL;DR: The anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.
Journal ArticleDOI
Docosahexaenoic Acid Protects from Dendritic Pathology in an Alzheimer's Disease Mouse Model
Frédéric Calon,Giselle P. Lim,Giselle P. Lim,Fusheng Yang,Fusheng Yang,Takashi Morihara,Takashi Morihara,Bruce Teter,Bruce Teter,Oliver J. Ubeda,Oliver J. Ubeda,Phillippe Rostaing,Antoine Triller,Norman Salem,Karen H. Ashe,Sally A. Frautschy,Sally A. Frautschy,Greg M. Cole,Greg M. Cole +18 more
TL;DR: Reduction of dietary n-3 PFA in an AD mouse model resulted in 80%-90% losses of the p85alpha subunit of phosphatidylinositol 3-kinase and the postsynaptic actin-regulating protein drebrin, as in AD brain.
Journal ArticleDOI
A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model.
Giselle P. Lim,Frédéric Calon,Takashi Morihara,Fusheng Yang,Bruce Teter,Oliver J. Ubeda,Norman Salem,Sally A. Frautschy,Greg M. Cole +8 more
TL;DR: DHA modulated APP processing by decreasing both α- and β-APP C-terminal fragment products and full-length APP, which suggests DHA could be protective against β-amyloid production, accumulation, and potential downstream toxicity.
Journal ArticleDOI
β-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin
Qiu-Lan Ma,Fusheng Yang,Emily R. Rosario,Oliver J. Ubeda,Walter Beech,Dana J. Gant,Ping-Ping Chen,Beverly Hudspeth,Cory Chen,Yongle Zhao,Harry V. Vinters,Sally A. Frautschy,Greg M. Cole +12 more
TL;DR: Data indicate JNK mediates Aβ oligomer inactivation of IRS-1 and phospho-tau pathology and that dietary treatment with fish oil/DHA, curcumin, or a combination of both has the potential to improve insulin/trophic signaling and cognitive deficits in AD.