Protective actions of sex steroid hormones in Alzheimer's disease.
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TLDR
The successful use of hormone therapies in aging men and women to delay, prevent, and or treat AD will require additional research to optimize key parameters of hormone therapy and may benefit from the continuing development of selective estrogen and androgen receptor modulators.About:
This article is published in Frontiers in Neuroendocrinology.The article was published on 2009-05-07 and is currently open access. It has received 445 citations till now. The article focuses on the topics: Estrogen & Testosterone.read more
Citations
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Journal ArticleDOI
Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines
Glenda Gillies,Simon McArthur +1 more
TL;DR: This review focuses on sex dimorphisms in the ability of estradiol to influence synaptic plasticity, neurotransmission, neurodegeneration, and cognition, which, it is argued, are due in a large part to sex differences in the organization of the underlying circuitry.
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Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential.
TL;DR: This review provides an overview and update of compounds that have been recently reported as modulators of ERs, with a particular focus on their potential clinical applications.
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Sex and the development of Alzheimer's disease.
TL;DR: The combined effects of organizational and activational effects of sex steroids yield distinct sex differences in AD pathogenesis, a significant variable that must be more rigorously considered in future research.
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Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues
Davide Brambilla,Benjamin Le Droumaguet,Julien Nicolas,S. Hossein Hashemi,Lin-Ping Wu,S. Moein Moghimi,Patrick Couvreur,Karine Andrieux +7 more
TL;DR: There are concerns regarding the initiation of possible NP-mediated adverse events in AD, thus demanding the use of precisely assembled nanoconstructs from biocompatible materials.
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Androgen Therapy in Women: A Reappraisal: An Endocrine Society Clinical Practice Guideline
Margaret E. Wierman,Margaret E. Wierman,Wiebke Arlt,Rosemary Basson,Susan R. Davis,Karen K. Miller,Mohammad Hassan Murad,William Rosner,Nanette Santoro +8 more
TL;DR: Evidence supports the short-term efficacy and safety of high physiological doses of T treatment of postmenopausal women with sexual dysfunction due to hypoactive sexual desire disorder and no long-term safety data are lacking.
References
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Alzheimer's disease: the amyloid cascade hypothesis
John Hardy,Gerald A. Higgins +1 more
TL;DR: An extensive catalog of genes that act in a migrating cell is provided, unique molecular functions involved in nematode cell migration are identified, and similar functions in humans are suggested.
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TL;DR: Findings in other neurodegenerative diseases indicate that a broadly similar process of neuronal dysfunction is induced by diffusible oligomers of misfolded proteins.
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Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TL;DR: By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.
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Antioxidant properties of phenolic compounds
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