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Emma A. Meagher
Researcher at University of Pennsylvania
Publications - 39
Citations - 1992
Emma A. Meagher is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Lomitapide & Familial hypercholesterolemia. The author has an hindex of 15, co-authored 34 publications receiving 1806 citations.
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Journal ArticleDOI
Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study.
Marina Cuchel,Emma A. Meagher,Hendrik Du Toit Theron,Dirk J. Blom,Dirk J. Blom,A. David Marais,A. David Marais,Robert A. Hegele,Maurizio Averna,Cesare R. Sirtori,Prediman K. Shah,Daniel Gaudet,Claudia Stefanutti,Giovanni Battista Vigna,Anna M. E. Du Plessis,Kathleen J. Propert,William J. Sasiela,LeAnne T. Bloedon,Daniel J. Rader +18 more
TL;DR: Treatment with lomitapide could be a valuable drug in the management of homozygous familial hypercholesterolaemia, according to the FDA Office of the Orphan Product Development.
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Indices of lipid peroxidation in vivo: strengths and limitations
TL;DR: Measurement of 4-hydroxynonenal and a variety of isoprostanes in urine reflects lipid peroxidation in vivo and offers a noninvasive approach that may be readily applied to clinical trials.
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Effects of vitamin E on lipid peroxidation in healthy persons.
TL;DR: The results question the rationale for vitamin E supplementation in healthy individuals and specific quantitative indices of oxidative stress in vivo should be considered as entry criteria and for dose selection in clinical trials of antioxidant drugs and vitamins in human disease.
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Alcohol-induced generation of lipid peroxidation products in humans
Emma A. Meagher,Orla P. Barry,Anne Burke,Michael R. Lucey,John A. Lawson,Joshua Rokach,Garret A. FitzGerald +6 more
TL;DR: Increased generation of iPs by alcohol in healthy volunteers is consistent with the hypothesis that oxidant stress precedes and contributes to the evolution of ALD.
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Safety and effectiveness of Niaspan when added sequentially to a statin for treatment of dyslipidemia.
Megan L. Wolfe,Sara F. Vartanian,Joyce L. Ross,Lori-Lynn Bansavich,Emile R. Mohler,Emma A. Meagher,Christopher A. Friedrich,Daniel J. Rader +7 more
TL;DR: Niaspan, when added to a stable dose of a statin in 66 subjects, was found to be safe and highly effective in improving lipid parameters.