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Emma C. Moran
Researcher at Wake Forest Institute for Regenerative Medicine
Publications - 13
Citations - 673
Emma C. Moran is an academic researcher from Wake Forest Institute for Regenerative Medicine. The author has contributed to research in topics: Decellularization & Regenerative medicine. The author has an hindex of 10, co-authored 13 publications receiving 593 citations. Previous affiliations of Emma C. Moran include Wake Forest University.
Papers
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Journal ArticleDOI
Production and implantation of renal extracellular matrix scaffolds from porcine kidneys as a platform for renal bioengineering investigations.
Giuseppe Orlando,Alan C. Farney,Samy S. Iskandar,Sayed-Hadi Mirmalek-Sani,David C. Sullivan,Emma C. Moran,Tamer Aboushwareb,Paolo De Coppi,Kathryn J. Wood,Robert J. Stratta,Anthony Atala,James J. Yoo,Shay Soker +12 more
TL;DR: Investigations show that pig kidneys can be successfully decellularized to produce renal ECM scaffolds, which maintain their basic components, are biocompatible, and show intact, though thrombosed, vasculature.
Journal ArticleDOI
Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies
Giuseppe Orlando,Christopher Booth,Zhan Wang,Giorgia Totonelli,Christina L Ross,Emma C. Moran,Marcus Salvatori,Panagiotis Maghsoudlou,Mark Turmaine,Ginger T. DeLario,Y. Al-Shraideh,Umar Farooq,Alan C. Farney,Jeffrey Rogers,Samy S. Iskandar,Alan J. Burns,Frank C. Marini,Paolo De Coppi,Robert J. Stratta,Shay Soker +19 more
TL;DR: Results indicate that discarded human kidneys are a suitable source of renal scaffolds and their use for tissue engineering applications may be more clinically applicable than kidneys derived from animals.
Journal ArticleDOI
Self‐assembled liver organoids recapitulate hepatobiliary organogenesis in vitro
Dipen Vyas,Pedro M. Baptista,Matthew Brovold,Emma C. Moran,Brandon Gaston,Chris Booth,Michael Samuel,Anthony Atala,Shay Soker +8 more
TL;DR: It is shown that human fetal liver progenitor cells self‐assembled inside acellular liver extracellular matrix scaffolds to form three‐dimensional liver organoids that recapitulated several aspects of hepatobiliary organogenesis and resulted in concomitant formation of progressively more differentiated hepatocytes and bile duct structures.
Journal ArticleDOI
Scale-dependent mechanical properties of native and decellularized liver tissue.
TL;DR: In this paper, the biomechanical properties of perfused liver tissue in its native and decellularized states on both a macro-and nano-scale were analyzed using poroviscoelastic finite element models.
Book ChapterDOI
Human Liver Bioengineering Using a Whole Liver Decellularized Bioscaffold
TL;DR: This chapter describes in detail the necessary steps in human liver bioengineering, which include ferret liver decellularization by detergent perfusion, human liver progenitor and endothelial cell isolation, and finally, liver bioscaffold recellularization in a perfusion bioreactor.