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Emma J. Manners
Researcher at European Bioinformatics Institute
Publications - 4
Citations - 757
Emma J. Manners is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 2 publications receiving 420 citations.
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Journal ArticleDOI
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Mehdi Bouhaddou,Danish Memon,Bjoern Meyer,Kris M. White,Veronica V. Rezelj,Miguel Correa Marrero,Benjamin J. Polacco,James E. Melnyk,Svenja Ulferts,Robyn M. Kaake,Jyoti Batra,Alicia L. Richards,Erica Stevenson,David E. Gordon,Ajda Rojc,Kirsten Obernier,Jacqueline M. Fabius,Margaret Soucheray,Lisa Miorin,Elena Moreno,Cassandra Koh,Quang Dinh Tran,Alexandra Hardy,Rémy Robinot,Thomas Vallet,Benjamin E. Nilsson-Payant,Claudia Hernandez-Armenta,Alistair Dunham,Sebastian Weigang,Julian Knerr,Maya Modak,Diego Quintero,Yuan Zhou,Aurelien Dugourd,Alberto Valdeolivas,Trupti Patil,Qiongyu Li,Ruth Hüttenhain,Merve Cakir,Monita Muralidharan,Minkyu Kim,Gwendolyn M. Jang,Beril Tutuncuoglu,Joseph Hiatt,Jeffrey Z. Guo,Jiewei Xu,Sophia Bouhaddou,Christopher J.P. Mathy,Anna Gaulton,Emma J. Manners,Eloy Felix,Ying Shi,Marisa Goff,Jean K. Lim,Timothy McBride,Michael C. O’Neal,Yiming Cai,Jason C.J. Chang,David J. Broadhurst,Saker Klippsten,Emmie de Wit,Andrew R. Leach,Tanja Kortemme,Brian K. Shoichet,Melanie Ott,Julio Saez-Rodriguez,Benjamin R. tenOever,R. Dyche Mullins,Elizabeth R. Fischer,Georg Kochs,Robert Grosse,Adolfo García-Sastre,Marco Vignuzzi,Jeffery R. Johnson,Kevan M. Shokat,Danielle L. Swaney,Pedro Beltrao,Nevan J. Krogan +77 more
TL;DR: A quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells reveals dramatic rewiring of phosphorylation on host and viral proteins, revealing potential COVID-19 therapies.
Journal ArticleDOI
Target-Based Evaluation of "Drug-Like" Properties and Ligand Efficiencies.
Paul D. Leeson,A. Patrícia Bento,Anna Gaulton,Anne Hersey,Emma J. Manners,Chris J Radoux,Andrew R. Leach +6 more
TL;DR: In this paper, physicochemical descriptors commonly used to define drug-likeness and ligand efficiency measures are assessed for their ability to differentiate marketed drugs from compounds reported to bind to their efficacious target or targets.
Journal ArticleDOI
KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study
TL;DR: In this article , a network-based approach for visualizing and interpreting drug-protein and protein-protein interactions is presented. But, the work is limited to the DILIRank dataset, where compounds are categorized by their likeliness of causing DILI.
Journal ArticleDOI
Genetic characterization of Salmonella Infantis from South Africa, 2004–2016
Jennifer Mattock,Karen H. Keddy,Emma J. Manners,Sanelisiwe T. Duze,Shannon L. Smouse,Nomsa P. Tau,David Baker,Marie Anne Chattaway,Alison E. Mather,John Wain,Gemma C. Langridge +10 more
TL;DR: Comparison of the pan-genomes of isolates from either eBG or eBG297 identified 943 genes significantly associated with eBG, which suggests that eBG31 and e BG297 isolates occupy different niches within South Africa, if antibiotic-resistant S. Infantis emerges in South Africa.