J
Jeffery R. Johnson
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 9
Citations - 883
Jeffery R. Johnson is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Cilium & Kinase. The author has an hindex of 4, co-authored 7 publications receiving 525 citations. Previous affiliations of Jeffery R. Johnson include Gladstone Institutes & University of California, San Francisco.
Papers
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Journal ArticleDOI
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Mehdi Bouhaddou,Danish Memon,Bjoern Meyer,Kris M. White,Veronica V. Rezelj,Miguel Correa Marrero,Benjamin J. Polacco,James E. Melnyk,Svenja Ulferts,Robyn M. Kaake,Jyoti Batra,Alicia L. Richards,Erica Stevenson,David E. Gordon,Ajda Rojc,Kirsten Obernier,Jacqueline M. Fabius,Margaret Soucheray,Lisa Miorin,Elena Moreno,Cassandra Koh,Quang Dinh Tran,Alexandra Hardy,Rémy Robinot,Thomas Vallet,Benjamin E. Nilsson-Payant,Claudia Hernandez-Armenta,Alistair Dunham,Sebastian Weigang,Julian Knerr,Maya Modak,Diego Quintero,Yuan Zhou,Aurelien Dugourd,Alberto Valdeolivas,Trupti Patil,Qiongyu Li,Ruth Hüttenhain,Merve Cakir,Monita Muralidharan,Minkyu Kim,Gwendolyn M. Jang,Beril Tutuncuoglu,Joseph Hiatt,Jeffrey Z. Guo,Jiewei Xu,Sophia Bouhaddou,Christopher J.P. Mathy,Anna Gaulton,Emma J. Manners,Eloy Felix,Ying Shi,Marisa Goff,Jean K. Lim,Timothy McBride,Michael C. O’Neal,Yiming Cai,Jason C.J. Chang,David J. Broadhurst,Saker Klippsten,Emmie de Wit,Andrew R. Leach,Tanja Kortemme,Brian K. Shoichet,Melanie Ott,Julio Saez-Rodriguez,Benjamin R. tenOever,R. Dyche Mullins,Elizabeth R. Fischer,Georg Kochs,Robert Grosse,Adolfo García-Sastre,Marco Vignuzzi,Jeffery R. Johnson,Kevan M. Shokat,Danielle L. Swaney,Pedro Beltrao,Nevan J. Krogan +77 more
TL;DR: A quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells reveals dramatic rewiring of phosphorylation on host and viral proteins, revealing potential COVID-19 therapies.
Journal ArticleDOI
Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways
Monika Abedin Sigg,Tabea Menchen,Chaehee Lee,Jeffery R. Johnson,Melissa K. Jungnickel,Semil P. Choksi,Galo Garcia,Henriette Busengdal,Gerard W. Dougherty,Petra Pennekamp,Claudius Werner,Fabian Rentzsch,Harvey M. Florman,Nevan J. Krogan,John B. Wallingford,Heymut Omran,Jeremy F. Reiter +16 more
TL;DR: Proteomic profiling of cilia from diverse eukaryotes defines a conserved ciliary proteome, reveals ancient connections to signaling, and uncovers a ciliary protein that underlies development and human disease.
Journal ArticleDOI
A scaffold protein connects type IV pili with the Chp chemosensory system to mediate activation of virulence signaling in Pseudomonas aeruginosa
Yuki F. Inclan,Alexandre Persat,Alexander L. Greninger,John Von Dollen,John Von Dollen,Jeffery R. Johnson,Jeffery R. Johnson,Nevan J. Krogan,Nevan J. Krogan,Nevan J. Krogan,Zemer Gitai,Joanne N. Engel +11 more
TL;DR: It is proposed that FimL acts as a scaffold enabling spatial colocalization of TFP and Chp system components to coordinate signaling leading to cAMP‐dependent upregulation of virulence genes on surface contact.
Posted ContentDOI
The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity
Adrienne E.D. Stormo,Molly FitzGibbon,Farbod Shavarebi,Elizabeth M. Earley,Lotus S. Lum,Erik Verschueren,Danielle L. Swaney,Gaia Skibinski,Abinaya Ravisankar,Jeffery van Haren,Emily J. Davis,Jeffery R. Johnson,John Von Dollen,Christian Mirescu,Ciro Iaccarino,William T. Dauer,R. Jeremy Nichols,Torsten Wittmann,Timothy C. Cox,Steve Finkbeiner,Nevan J. Krogan,Nevan J. Krogan,Scott A. Oakes,Scott A. Oakes,Annie Hiniker,Annie Hiniker +25 more
TL;DR: In this article, the authors performed quantitative mass spectrometry-based interactome studies to identify 48 novel LRRK2 interactors, including the microtubule-associated E3 ubiquitin ligase TRIM1 (Tripartite Motif Family 1).
Book ChapterDOI
The Virus–Host Interactome: Knowing the Players to Understand the Game
TL;DR: In this paper, the authors examine the information that can be gained from genome-and proteome-level analyses of host-pathogen interactions, the advantages and pitfalls of various methods and provide examples of significant breakthroughs that have been facilitated using OMICs-based technologies.