E
Eric Espinosa
Researcher at French Institute of Health and Medical Research
Publications - 41
Citations - 2410
Eric Espinosa is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Mast cell & T cell. The author has an hindex of 20, co-authored 38 publications receiving 2139 citations. Previous affiliations of Eric Espinosa include Centre national de la recherche scientifique & University of Toulouse.
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Journal ArticleDOI
The same tyrosine-based inhibition motif, in the intra-cytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation
Marc Daëron,Sylvain Latour,Odile Malbec,Eric Espinosa,Patrick Pina,Suzanne G.M.A. Pasmans,Wolf H. Fridman +6 more
TL;DR: This work shows that the same tyrosine-based inhibitory motif (ITIM), which is highly conserved in murine and human Fc gamma RIIB and that was previously shown to inhibit BCR-dependent B cell activation, was required to regulate TCR- and FcR-dependent cell activation.
Journal ArticleDOI
Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells
Emma Lefrançais,Anais Duval,Anais Duval,Emilie Mirey,Emilie Mirey,Stéphane Roga,Stéphane Roga,Eric Espinosa,Corinne Cayrol,Corinne Cayrol,Jean-Philippe Girard,Jean-Philippe Girard +11 more
TL;DR: It is found that serine proteases secreted by activated mast cells generate mature forms of IL-33 with potent activity on ILC2s, which are 30-fold more potent than full-length human IL-331–270 for activation of I LC2s ex vivo.
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Different activation signals induce distinct mast cell degranulation strategies
Nicolas Gaudenzio,Riccardo Sibilano,Thomas Marichal,Philipp Starkl,Laurent L. Reber,Nicolas Cenac,Benjamin D. McNeil,Xinzhong Dong,Joseph D. Hernandez,Ronit Sagi-Eisenberg,Ilan Hammel,Axel Roers,Salvatore Valitutti,Mindy Tsai,Eric Espinosa,Stephen J. Galli +15 more
TL;DR: These findings show that cytoplasmic granule secretion from MCs that occurs in response to different activating stimuli can exhibit distinct dynamics and features that are associated with distinct patterns of MC-dependent inflammation.
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Chemical synthesis and biological activity of bromohydrin pyrophosphate, a potent stimulator of human gamma delta T cells.
Eric Espinosa,Christian Belmant,Frédéric Pont,Béatrice Luciani,Rémy Poupot,François Romagné,Hervé Brailly,Marc Bonneville,Jean-Jacques Fournié +8 more
TL;DR: BrHPP is a novel molecule enabling potent immunostimulation of human γδ T lymphocytes and can be obtained in gram amounts, is easy to detect, and is of high stability in aqueous solutions.
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Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors
Sandrine Poglio,Sandrine Poglio,Fabienne De Toni-Costes,Fabienne De Toni-Costes,Emmanuelle Arnaud,Emmanuelle Arnaud,Patrick Laharrague,Eric Espinosa,Eric Espinosa,Louis Casteilla,Louis Casteilla,Béatrice Cousin,Béatrice Cousin +12 more
TL;DR: It is demonstrated that adipose‐derived HSPC contain a precursor‐cell population committed to the mast cell lineage, and able to efficiently home to peripheral organs such as intestine and skin, where it acquires properties of functional tissue mast cells.