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Emmani B.M. Nascimento
Researcher at Maastricht University
Publications - 36
Citations - 1262
Emmani B.M. Nascimento is an academic researcher from Maastricht University. The author has contributed to research in topics: Brown adipose tissue & Adipose tissue. The author has an hindex of 16, co-authored 36 publications receiving 999 citations. Previous affiliations of Emmani B.M. Nascimento include Leiden University Medical Center & Leiden University.
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Journal ArticleDOI
The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity
Evie P.M. Broeders,Emmani B.M. Nascimento,Bas Havekes,Boudewijn Brans,Kay H. M. Roumans,Anne Tailleux,Gert Schaart,Mostafa Kouach,Julie Charton,Benoit Deprez,Nicole D. Bouvy,Felix M. Mottaghy,Bart Staels,Wouter D. van Marken Lichtenbelt,Patrick Schrauwen +14 more
TL;DR: In vitro treatment of primary human brown adipocytes derived with CDCA or specific TGR5 agonists increased mitochondrial uncoupling and D2 expression, an effect that was absent in human primary white adipocytes.
Journal ArticleDOI
Low brown adipose tissue activity in endurance-trained compared with lean sedentary men
Maarten J. Vosselman,Joris Hoeks,Boudewijn Brans,Hannah Pallubinsky,Emmani B.M. Nascimento,A A J J van der Lans,Evie P.M. Broeders,Felix M. Mottaghy,Patrick Schrauwen,W.D. van Marken Lichtenbelt +9 more
TL;DR: These results indicate that chronic endurance exercise is not associated with brown and beige adipocyte recruitment; in fact endurance training appears to be linked to lower the metabolic activity of BAT in humans.
Journal ArticleDOI
Role of PRAS40 in Akt and mTOR signaling in health and disease
TL;DR: The regulation and potential function(s) of PRAS40 in the complex Akt- and mTOR-signaling network in health and disease are summarized.
Journal ArticleDOI
Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.
Emmani B.M. Nascimento,Marieke Snel,Bruno Guigas,Gerard C.M. van der Zon,Jan Kriek,J. Antonie Maassen,J. Antonie Maassen,Ingrid M. Jazet,Michaela Diamant,D. Margriet Ouwens +9 more
TL;DR: It is concluded that PRAS40-Ser183 is a component of insulin action, and that efficient phosphorylation of PRAS 40-Ser 183 by mTORC1 requires the phosphorylated of PRas40-Thr246 by PKB/Akt.
Journal ArticleDOI
Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.
Emmani B.M. Nascimento,Mariann Fodor,Gerard C.M. van der Zon,Ingrid M. Jazet,A. Edo Meinders,Peter J. Voshol,Ronald Vlasblom,Bart Baan,Jürgen Eckel,J. Antonie Maassen,Michaela Diamant,D. Margriet Ouwens +11 more
TL;DR: Phosphorylation of PRAS40 is increased by insulin in human, rat, and mouse insulin target tissues and is reduced under conditions of HFD-induced insulin resistance, while in rats fed a high-fat diet (HFD), this response is reduced.