Emmanuelle H. Crost

TL;DR: This review focuses on recent findings unraveling the molecular strategies used by mucin-degrading bacteria to utilize host glycans, adapt to the mucosal environment, and influence human health.

TL;DR: It is shown that although both strains could assimilate mucin monosaccharides, only R. gnavus ATCC 29149 was able to grow on mucin as a sole carbon source, and a novel pathway by which R.gnavusATCC29149 utilises sialic acid from sialylated substrates is uncovered, advancing understanding of the role of gut commensals in health and disease.

TL;DR: The results uncover a previously unrecognized enzymatic activity in the gut microbiota, which may contribute to the adaptation of intestinal bacteria to the mucosal environment in health and disease.

TL;DR: Together this study showed a direct competition between R. bromii and R. gnavus on RS, suggesting that in vivo, the R. Gnavus population inhabiting the mucus niche may be modulated by the supply of non-digestible carbohydrates reaching the colon such as RS.

TL;DR: In this paper, the authors have obtained and analyzed the draft genome sequence of another R. gnavus mucin-degrader, ATCC 35913, isolated from a healthy individual and showed that the Nan cluster was upregulated when the strains were grown in presence of mucin.